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首页> 外文期刊>Journal of Clinical Microbiology >Does a Feline Leukemia Virus Infection Pave the Way for Bartonella henselae Infection in Cats?
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Does a Feline Leukemia Virus Infection Pave the Way for Bartonella henselae Infection in Cats?

机译：猫白血病病毒感染是否会为猫中的汉氏巴尔通体感染铺平道路？

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Domestic cats serve as the reservoir hosts of Bartonella henselae and may develop mild clinical symptoms or none after experimental infection. In humans, B. henselae infection can result in self-limiting cat scratch disease. However, immunocompromised patients may suffer from more-severe courses of infection or may even develop the potentially lethal disease bacillary angiomatosis. It was reasoned that cats with immunocompromising viral infections may react similarly to B. henselae infection. The aim of our study was to investigate the influence of the most important viruses known to cause immunosuppression in cats—Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), and Feline panleukopenia virus (FPV)—on natural B. henselae infection in cats. Accordingly, 142 cats from animal shelters were necropsied and tested for B. henselae and concurrent infections with FeLV, FIV, or FPV by PCR and immunohistochemistry. A significant association was found between B. henselae and FeLV infections (P = 0.00028), but not between B. henselae and FIV (P = 1.0) or FPV (P = 0.756) infection, age (P = 0.392), or gender (P = 0.126). The results suggest that susceptibility to B. henselae infection is higher in cats with concurrent FeLV infections, regardless of whether the infection is latent or progressive. Histopathology and immunohistochemistry for B. henselae failed to identify lesions that could be attributed specifically to B. henselae infection. We conclude that the course of natural B. henselae infection in cats does not seem to be influenced by immunosuppressive viral infections in general but that latent FeLV infection may predispose cats to B. henselae infection or persistence.
机译：家猫可作为 Bartonella henselae 的宿主宿主，可能会出现轻微的临床症状，或者在实验性感染后可能不会出现。在人类中， B。 henselae 感染可导致自限性猫抓病。然而，免疫功能低下的患者可能遭受更严重的感染过程，甚至可能发展出潜在致命的细菌性血管瘤病。有理由认为，免疫功能低下的病毒感染的猫可能与 B反应类似。 henselae 感染。我们的研究目的是调查已知可导致猫免疫抑制的最重要病毒-猫白血病病毒（FeLV），猫免疫缺陷病毒（FIV），和猫泛白细胞减少症病毒（FPV）-在天然 B上。 henselae 感染猫。因此，对来自动物收容所的142只猫进行尸检并测试B。 PCR和免疫组化检测Henselae 和并发FeLV，FIV或FPV感染。发现 B之间存在显着关联。 henselae 和FeLV感染（ P = 0.00028），但不在 B之间。 henselae 和FIV（ P = 1.0）或FPV（ P = 0.756）感染，年龄（ P = 0.392）或性别（ P = 0.126）。结果表明对 B的易感性。并发FeLV感染的猫的henselae 感染率更高，无论该感染是潜伏性感染还是进行性感染。 B的组织病理学和免疫组化。 henselae 无法识别出可能归因于 B的病变。 henselae 感染。我们得出结论，自然 B的过程。通常，猫的henselae 感染似乎不受免疫抑制病毒感染的影响，但是潜在的FeLV感染可能会使猫患 B。 henselae 感染或持续存在。

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