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首页> 外文期刊>Journal of Clinical Microbiology >Culture-Negative Prosthetic Valve Endocarditis with Concomitant Septicemia Due to a Nontoxigenic Corynebacterium diphtheriae Biotype Gravis Isolate in a Patient with Multiple Risk Factors
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Culture-Negative Prosthetic Valve Endocarditis with Concomitant Septicemia Due to a Nontoxigenic Corynebacterium diphtheriae Biotype Gravis Isolate in a Patient with Multiple Risk Factors

机译：具有多种风险因素的非毒素性白喉棒状杆菌生物型Gravis分离株导致的培养阴性的人工瓣膜性心内膜炎合并败血病

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摘要

A 54-year-old female with a prosthetic mitral valve presented with a 3-day history of dizziness, subjective fever, and chills. Blood cultures were positive for a pleomorphic Gram-positive rod. Initial phenotypic testing could only support the identification of a Corynebacterium species. Nucleic acid sequencing (16S rRNA) and matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) were conclusive for Corynebacterium diphtheriae. Definitive phenotypic testing classified the strain as nontoxigenic C. diphtheriae biotype Gravis.
机译：一名54岁的二尖瓣假体女性，有3天的头晕，主观发烧和发冷的病史。血培养对多形革兰氏阳性杆呈阳性。最初的表型测试只能支持棒杆菌属物种的鉴定。核酸测序（16S rRNA）和基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF MS）对于白喉棒杆菌具有决定性意义。明确的表型测试将该菌株归类为非毒性白喉衣原体生物型Gravis。

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