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首页> 外文期刊>Journal of Clinical Microbiology >Emergence of an Invasive Clone of Nontoxigenic Corynebacterium diphtheriae in the Urban Poor Population of Vancouver, Canada
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Emergence of an Invasive Clone of Nontoxigenic Corynebacterium diphtheriae in the Urban Poor Population of Vancouver, Canada

机译:在加拿大温哥华的城市贫困人口中,非毒素性白喉棒状杆菌侵入性克隆的出现

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Invasive disease due to Corynebacterium diphtheriae is rare in North America. Here we describe the emergence of a predominant clone of a nontoxigenic strain of C. diphtheriae in the impoverished population of Vancouver's downtown core. This clone has caused significant morbidity and contributed to at least two deaths. Over a 5-year period, seven cases of bacteremia due to C. diphtheriae were detected in patients admitted to Vancouver hospitals. Injection drug use, diabetes mellitus, skin colonization/infection with C. diphtheriae, and homelessness all appeared to be related to the development of bacteremia with the organism. Ribotyping of isolates recovered from blood culture revealed a predominant ribotype pattern that has not previously been reported in North America.
机译:白喉棒杆菌引起的侵袭性疾病在北美很少见。在这里,我们描述了 C的非产毒菌株的主要克隆的出现。温哥华市中心的贫困人口中的白喉。该克隆已引起大量发病,并导致至少两次死亡。在5年中,有7例因 C引起的菌血症。在温哥华医院收治的患者中发现了白喉。注射药物的使用,糖尿病,皮肤定植/感染 C。白喉和无家可归似乎都与生物体菌血症的发展有关。从血液培养物中分离出的分离株的核糖体分型显示出主要的核糖型模式,以前在北美尚未报道。

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