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首页> 外文期刊>Journal of Clinical Microbiology >Coagulase-Negative Staphylococcal Skin Carriage among Neonatal Intensive Care Unit Personnel: from Population to Infection
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Coagulase-Negative Staphylococcal Skin Carriage among Neonatal Intensive Care Unit Personnel: from Population to Infection

机译：重症监护病房人员中凝固酶阴性葡萄球菌皮肤运输：从人群到感染。

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Coagulase-negative staphylococci (CoNS) are a major cause of sepsis in neonatal intensive care units (NICU) worldwide. Infecting strains of these commensal bacteria may originate from NICU personnel. Therefore, we studied the characteristics of CoNS isolates from NICU personnel and compared them to those of isolates from the general population and from sepsis patients. Furthermore, we studied the epidemiological effect on CoNS carriage of NICU personnel after a period of absence. In our study, we isolated CoNS from the thumbs of NICU personnel every 2 weeks during the summer of 2005 and sampled personnel returning from vacation and a control group from the general population. Furthermore, we collected sepsis isolates from this period. Isolates were tested for antibiotic resistance, mecA and icaA carriage, biofilm production, and genetic relatedness. We found that mecA and icaA carriage as well as penicillin, oxacillin, and gentamicin resistance were significantly more prevalent in CoNS strains from NICU personnel than in community isolates. Similar trends were observed when postvacation strains were compared to prevacation strains. Furthermore, genetic analysis showed that 90% of the blood isolates were closely related to strains found on the hands of NICU personnel. Our findings revealed that CoNS carried by NICU personnel differ from those in the general population. Hospital strains are replaced by community CoNS after a period of absence. NICU personnel are a likely cause for the cross-contamination of virulent CoNS that originate from the NICU to patients.
机译：凝固酶阴性葡萄球菌（CoNS）是全世界新生儿重症监护病房（NICU）败血症的主要原因。这些共生细菌的感染株可能来自重症监护病房。因此，我们研究了重症监护病房人员的CoNS分离株的特征，并将其与普通人群和败血症患者的分离株进行了比较。此外，我们研究了缺席一段时间后，NICU人员携带CoNS的流行病学影响。在我们的研究中，我们于2005年夏季每2周从NICU人员的拇指中分离出CoNS，并从休假返回的人员和普通人群的对照组中进行抽样调查。此外，我们收集了这一时期的败血症分离株。测试了分离物的抗生素抗性， mecA 和 icaA 转运，生物膜产生和遗传相关性。我们发现， mecA 和 icaA 转运以及青霉素，奥沙西林和庆大霉素的耐药性在NICU人员的CoNS株中比在社区分离株中更为普遍。当将休假后菌株与休假前菌株进行比较时，观察到相似的趋势。此外，遗传分析表明，90％的血液分离株与重症监护病房（NICU）人员手上发现的菌株密切相关。我们的发现表明，NICU人员携带的CoNS与普通人群不同。一段时间后，医院菌株由社区CoNS代替。 NICU人员可能是源自NICU的强毒CoNS交叉污染患者的原因。

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