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首页> 外文期刊>Journal of Clinical Microbiology >Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil
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Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil

机译：巴西南部大流行性流感A和社区呼吸道病毒感染的实验室诊断，流行病学和临床结果

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Community respiratory viruses (CRVs) are commonly associated with seasonal infections. They have been associated with higher morbidity and mortality among children, elderly individuals, and immunosuppressed patients. In April 2009, the circulation of a new influenza A virus (FLUA H1N1v) was responsible for the first influenza pandemic of this century. We report the clinical and epidemiological profiles of inpatients infected with CRVs or with FLUA H1N1v at a tertiary care hospital in southern Brazil. In addition, we used these profiles to evaluate survivor and nonsurvivor patients infected with FLUA H1N1v. Multiplex reverse transcription-PCR (RT-PCR) and real time RT-PCR were used to detect viruses in inpatients with respiratory infections. Record data from all patients were reviewed. A total of 171 patients were examined over a period of 16 weeks. Of these, 39% were positive for FLUA H1N1v, 36% were positive for CRVs, and 25% were negative. For the FLUA H1N1v- and CRV-infected patients, epidemiological data regarding median age (30 and 1.5 years), myalgia (44% and 13%), need for mechanical ventilation (44% and 9%), and mortality (35% and 9%) were statistically different. In a multivariate analysis comparing survivor and nonsurvivor patients infected with influenza A virus H1N1, median age and creatine phosphokinase levels were significantly associated with a severe outcome. Seasonal respiratory infections are a continuing concern. Our results highlight the importance of studies on the prevalence and severity of these infections and that investments in programs of clinical and laboratory monitoring are essential to detect the appearance of new infective agents.
机译：社区呼吸道病毒（CRV）通常与季节性感染相关。它们与儿童，老年人和免疫抑制患者的较高发病率和死亡率相关。 2009年4月，新的甲型流感病毒（FLUA H1N1v）的传播是本世纪首例流感大流行的原因。我们报告了巴西南部一家三级护理医院感染CRV或FLUA H1N1v的住院患者的临床和流行病学概况。此外，我们使用这些配置文件来评估感染了FLUA H1N1v的存活者和非存活者。多重逆转录PCR（RT-PCR）和实时RT-PCR用于检测呼吸道感染住院患者的病毒。回顾了所有患者的记录数据。在16周内检查了171例患者。其中，39％的FLUA H1N1v阳性，CRV的阳性，而25％的阴性。对于感染FLUA H1N1v和CRV的患者，有关中位年龄（30岁和1.5岁），肌痛（44％和13％），需要机械通气（44％和9％）以及死亡率（35％和30％）的流行病学数据9％）有统计学差异。在比较感染甲型流感病毒H1N1的幸存者和非幸存者患者的多变量分析中，年龄中位数和肌酸磷酸激酶水平与严重预后显着相关。季节性呼吸道感染是一个持续的问题。我们的结果凸显了对这些感染的发生率和严重性进行研究的重要性，并且对临床和实验室监测计划的投资对于检测新的感染因子的出现至关重要。

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