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首页> 外文期刊>Journal of Clinical Microbiology >Emergence and Prevalence of Non-H2S-Producing Salmonella enterica Serovar Senftenberg Isolates Belonging to Novel Sequence Type 1751 in China
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Emergence and Prevalence of Non-H2S-Producing Salmonella enterica Serovar Senftenberg Isolates Belonging to Novel Sequence Type 1751 in China

机译：中国新序列类型1751的非H2S产肠炎沙门氏菌Senftenberg分离株的出现和流行。

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Salmonella enterica serovar Senftenberg is a common nontyphoidal Salmonella serotype which causes human Salmonella infections worldwide. In this study, 182 S. Senftenberg isolates, including 17 atypical non-hydrogen sulfide (H2S)-producing isolates, were detected in China from 2005 to 2011. The microbiological and genetic characteristics of the non-H2S-producing and selected H2S-producing isolates were determined by using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and clustered regularly interspaced short palindromic repeat (CRISPR) analysis. The phs operons were amplified and sequenced. The 17 non-H2S-producing and 36 H2S-producing isolates belonged to 7 sequence types (STs), including 3 new STs, ST1751, ST1757, and ST1758. Fourteen of the 17 non-H2S-producing isolates belonged to ST1751 and had very similar PFGE patterns. All 17 non-H2S-producing isolates had a nonsense mutation at position 1621 of phsA. H2S-producing and non-H2S-producing S. Senftenberg isolates were isolated from the same stool sample from three patients; isolates from the same patients displayed the same antimicrobial susceptibility, ST, and PFGE pattern but could be discriminated based on CRISPR spacers. Non-H2S-producing S. Senftenberg isolates belonging to ST1751 have been prevalent in Shanghai, China. It is possible that these emerging organisms will disseminate further, because they are difficult to detect. Thus, we should strengthen the surveillance for the spread of this atypical S. Senftenberg variant.
机译：肠炎沙门氏菌血清Senftenberg是一种常见的非伤寒沙门氏菌血清型，可导致全球人类沙门氏菌感染。在这项研究中，有182个 S 。 2005年至2011年在中国检测到Senftenberg分离株，包括17种非典型的非硫化氢（H 2 S）产菌。非H 2 <通过使用脉冲场凝胶电泳（PFGE），多基因座序列分型（MLST）和成簇规则间隔的短回文重复序列（CRISPR）确定产生/ sub> S的细菌和选定的产生H 2 S的菌株）分析。对h> phs 操纵子进行扩增和测序。产生17个非H 2 S的菌株和36个产生H 2 S的菌株分别属于7个序列类型（ST），包括3个新的ST，ST1751，ST1757和ST1758。 17个非H 2 产生菌的菌株中有14个属于ST1751，并且具有非常相似的PFGE模式。全部17个非H 2 S产生菌均在 phsA 的1621位具有无义突变。产生H 2 S和不产生H 2 S的 S 。从三名患者的相同粪便样本中分离出Senftenberg分离株。来自同一患者的分离株显示出相同的抗药性，ST和PFGE模式，但可以根据CRISPR间隔区进行区分。产生非H 2 S的 S 。属于ST1751的Senftenberg分离株已在中国上海流行。这些新兴生物可能会进一步传播，因为它们很难被发现。因此，我们应该加强对这种非典型 S 扩散的监视。 Senftenberg变体。

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