Detection of Oseltamivir Resistance during Treatment of 2009 H1N1 Influenza Virus Infection in Immunocompromised Patients: Utility of Cycle Threshold Values of Qualitative Real-Time Reverse Transcriptase PCR

Tejal Mehta; Eric McGrath; Suchitha Bheemreddy; Hossein Salimnia; Nahed Abdel-Haq; Jocelyn Y. Ang; Lawrence Lum; Pranatharthi Chandrasekar; George J. Alangaden

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Detection of Oseltamivir Resistance during Treatment of 2009 H1N1 Influenza Virus Infection in Immunocompromised Patients: Utility of Cycle Threshold Values of Qualitative Real-Time Reverse Transcriptase PCR

机译：免疫功能低下患者治疗2009 H1N1流感病毒感染期间对Oseltamivir耐药性的检测：定性实时逆转录酶PCR的循环阈值实用性

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Two immunocompromised patients with 2009 H1N1 influenza pneumonia had viral shedding for over 5 weeks despite therapy with oseltamivir. Declining or persistently low cycle threshold values noted on serial qualitative real-time reverse transcriptase PCR (rRT-PCR) of respiratory specimens implied increasing viral load and probable drug resistance. Oseltamivir resistance was later confirmed by pyrosequencing.

机译：尽管使用奥司他韦治疗，但两名免疫力低下的2009 H1N1流感肺炎患者的病毒脱落持续了超过5周。呼吸道标本的连续定性实时逆转录酶PCR（rRT-PCR）上注明的循环阈值下降或持续偏低，意味着病毒载量增加和可能的耐药性。后来通过焦磷酸测序证实了对奥司他韦的耐药性。

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《Journal of Clinical Microbiology》 |2010年第11期|共3页
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Tejal Mehta; Eric McGrath; Suchitha Bheemreddy; Hossein Salimnia; Nahed Abdel-Haq; Jocelyn Y. Ang; Lawrence Lum; Pranatharthi Chandrasekar; George J. Alangaden;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Rapid Detection of Influenza A Pandemic (H1N1) 2009 Virus Neuraminidase Resistance Mutation H275Y by Real-Time Reverse Transcriptase PCR [J] . Musa Hindiyeh, Daniela Ram, Michal Mandelboim, Journal of Clinical Microbiology . 2010,第5期

机译：实时逆转录酶PCR快速检测甲型流感（H1N1）2009病毒神经氨酸酶耐药突变H275Y
2. Development of a real-time RT-PCR assay for detection of resistance to oseltamivir in influenza A pandemic (H1N1) 2009 virus using single nucleotide polymorphism probes [J] . Wong Sallene, Pabbaraju Kanti, Wong Anita, Journal of Virological Methods . 2011,第2期

机译：使用单核苷酸多态性探针开发实时RT-PCR检测法以检测2009年甲型流感大流行（H1N1）病毒对奥司他韦的耐药性
3. Design and Performance of the CDC Real-Time Reverse Transcriptase PCR Swine Flu Panel for Detection of 2009 A (H1N1) Pandemic Influenza Virus [J] . Bo Shu, Kai-Hui Wu, Shannon Emery, Journal of Clinical Microbiology . 2011,第7期

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4. Detection of Oseltamivir Resistance during Treatment of 2009 H1N1 Influenza Virus Infection in Immunocompromised Patients: Utility of Cycle Threshold Values of Qualitative Real-Time Reverse Transcriptase PCR [O] . Tejal Mehta, Eric McGrath, Suchitha Bheemreddy, 2010

机译：免疫功能低下患者治疗2009 H1N1流感病毒感染期间对Oseltamivir耐药性的检测：定性实时逆转录酶PCR的循环阈值实用性
5. Detection of Oseltamivir Resistance during Treatment of 2009 H1N1 Influenza Virus Infection in Immunocompromised Patients: Utility of Cycle Threshold Values of Qualitative Real-Time Reverse Transcriptase PCR▿ [O] . Mehta, Tejal, McGrath, Eric, Bheemreddy, Suchitha, 2010

机译：在免疫功能低下的患者中治疗2009 H1N1流感病毒感染期间对奥司他韦耐药性的检测：定性实时逆转录酶PCR的循环阈值实用

Detection of Oseltamivir Resistance during Treatment of 2009 H1N1 Influenza Virus Infection in Immunocompromised Patients: Utility of Cycle Threshold Values of Qualitative Real-Time Reverse Transcriptase PCR

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