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首页> 外文期刊>Journal of Clinical Microbiology >Chlamydia trachomatis Strains Show Specific Clustering for Men Who Have Sex with Men Compared to Heterosexual Populations in Sweden, the Netherlands, and the United States
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Chlamydia trachomatis Strains Show Specific Clustering for Men Who Have Sex with Men Compared to Heterosexual Populations in Sweden, the Netherlands, and the United States

机译：与瑞典，荷兰和美国的异性恋人群相比，沙眼衣原体菌株显示出与男性发生性关系的男性的特定聚类

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摘要

High-resolution genotyping of Chlamydia trachomatis improves the characterization of strains infecting different patient groups and sexual networks. In this study, multilocus sequence typing (MLST) and ompA sequence determination were used for an analysis of C. trachomatis strains from 203 men who have sex with men (MSM) from Sweden, the Netherlands, and the United States. The results obtained were compared with data from 153 heterosexual women from Sweden and the Netherlands. The overlap in MLST/ompA profiles between MSM from Sweden and the Netherlands was 68%, while the overlap between heterosexual populations from these countries was only 18%. The distribution of genotypes in MSM from the United States was less similar to that in MSM from the European countries, with 45% and 46% overlaps for MSM in Sweden and the Netherlands, respectively. Minimum-spanning-tree analysis of MLST/ompA sequence types identified two large clusters that contained almost exclusively samples from MSM and comprised 74% of all MSM samples. Three other clusters were predominated by samples from women but also contained MSM specimens. Of 19 detected variants of the MLST target CT144, three variants were highly associated with MSM. Our study supports the hypotheses of both tissue tropism as well as epidemiological network structures as explanations for the linkage between specific genetic variants and sexual orientation.
机译：沙眼衣原体的高分辨率基因分型改善了感染不同患者群体和性网络的菌株的表征。在这项研究中，多位点序列分型（MLST）和 ompA 序列测定被用于分析来自瑞典，荷兰和德国的203名与男性发生性关系的男性沙眼衣原体菌株。美国。将获得的结果与来自瑞典和荷兰的153名异性恋妇女的数据进行了比较。瑞典和荷兰的男男性接触者之间的MLST / 分布重叠为68％，而这些国家的异性恋人群之间的重叠仅为18％。美国MSM的基因型分布与欧洲国家的MSM不太相似，瑞典和荷兰的MSM分别有45％和46％的重叠。 MLST / ompA 序列类型的最小生成树分析确定了两个大型簇，这些簇几乎只包含来自MSM的样本，占所有MSM样本的74％。其他三个簇以女性样本为主，但也包含MSM标本。在检测到的MLST目标CT144的19个变体中，有3个与MSM高度相关。我们的研究支持组织嗜性和流行病学网络结构的假设，作为特定遗传变异与性取向之间联系的解释。

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