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首页> 外文期刊>Journal of Clinical Microbiology >Emergence of a New Norovirus GII.4 Variant and Changes in the Historical Biennial Pattern of Norovirus Outbreak Activity in Alberta, Canada, from 2008 to 2013
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Emergence of a New Norovirus GII.4 Variant and Changes in the Historical Biennial Pattern of Norovirus Outbreak Activity in Alberta, Canada, from 2008 to 2013

机译:2008年至2013年在加拿大艾伯塔省出现的新型诺如病毒GII.4变异和诺如病毒暴发活动的历史双年度模式的变化

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The public health impact of the emergence of new norovirus (NoV) strains is uncertain. A biennial pattern of alternating quiescent and epidemic levels of NoV outbreak activity associated with the emergence of new GII.4 variants was observed in Alberta, Canada, between July 2000 and June 2008. In this study, NoV genogroup I (GI) and GII strains isolated from 710 outbreak specimens in Alberta between July 2008 and January 2013 were characterized to update historical data. The seasonality and annual variation in NoV outbreak burden were analyzed over a 10-year period (July 2002 to June 2012). We found that GII.4-2006b had persisted as the predominant variant over three observation periods (July 2006 to June 2009) during which the biennial NoV outbreak pattern continued. The emergence of GII.4-2010 (winter 2009) was not associated with increased outbreak activity, and outbreak activity between July 2009 and June 2012 when GII.4-2010 predominated (67.5 to 97.7%) did not follow a biennial pattern. GII.4-2012 first emerged in Alberta in September 2011 and became predominant in observation period July 2012 to June 2013. NoV GI, relatively rare in past years, had a higher activity level (37.3%) as represented by GI.6 and GI.7 in the winter of 2012 to 2013. A higher proportion of GI outbreaks occurred in non-health care facility settings compared to GII. Our study suggests that factors other than new variants emergence contribute to the levels of NoV outbreak activity in Alberta.
机译:新型诺如病毒(NoV)菌株的出现对公共卫生的影响尚不确定。在2000年7月至2008年6月之间,在加拿大艾伯塔省观察到与新的GII.4变种相关的NoV暴发活动交替交替的静态和流行水平的两年期模式。在这项研究中,NoV基因组I(GI)和GII菌株从2008年7月至2013年1月在艾伯塔省的710个暴发标本中分离出的特征用于更新历史数据。在10年期间(2002年7月至2012年6月)分析了NoV爆发负担的季节性和年度变化。我们发现,GII.4-2006b在三个观察期(2006年7月至2009年6月)期间一直是主要变异,在此期间,两年一度的NoV暴发持续。 GII.4-2010(2009年冬季)的出现与爆发活动的增加无关,在2009年7月至2012年6月GII.4-2010占主导地位(67.5至97.7%)的爆发活动未遵循两年期模式。 GII.4-2012于2011年9月首次出现在艾伯塔省,并在2012年7月至2013年6月的观察期中占主导地位。以GI.6和GI表示,NoV GI在过去几年中相对罕见,具有较高的活性水平(37.3%)。 .7在2012年至2013年冬季。与GII相比,在非医疗机构中发生的GI爆发比例更高。我们的研究表明,除了新变异的出现以外,其他因素也促进了艾伯塔省NoV爆发活动的水平。

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