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首页> 外文期刊>Journal of Clinical Microbiology >Anal Human Papillomavirus Genotype Distribution in HIV-Infected Men Who Have Sex with Men by Geographical Origin, Age, and Cytological Status in a Spanish Cohort
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Anal Human Papillomavirus Genotype Distribution in HIV-Infected Men Who Have Sex with Men by Geographical Origin, Age, and Cytological Status in a Spanish Cohort

机译：在西班牙队列中按地理位置，年龄和细胞学状况与男性发生性行为的艾滋病毒感染男性中肛门人类乳头瘤病毒基因型分布

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Knowledge of human papillomavirus (HPV) type distribution in populations at risk for anal cancer is needed. Here, we describe the anal HPV genotype distribution in a large Spanish cohort (Cohort of the Spanish HIV Research Network HPV [CoRIS-HPV]) of HIV-positive men who have sex with men (MSM) according to geographical origin, age, and cytological status. A cross-sectional analysis of baseline data from 1,439 HIV-infected MSM (2007 to 2012) was performed. Anal HPV genotyping was performed using the Linear Array HPV genotyping test. Descriptive analyses of subject characteristics, prevalences, and 95% confidence intervals (CI) were performed. The global prevalences of HPV, high-risk HPV (HR-HPV), and low-risk HPV (LR-HPV) types were 95.8%, 83.0%, and 72.7%, respectively. Among the HR-HPV types, HPV16 was the most common, followed by HPV59, -39, -51, -18, and -52. The prevalence of multiple HR-HPV infections was 58.5%. There were no differences in the crude analyses between Spanish and Latin-American MSM for most HPV types, and a peak in prevalence for most HPV types was seen in patients in their late thirties. Globally and by specific HPV groups, men with abnormal anal cytologies had a higher prevalence of infection than those with normal cytologies. This study has the largest number of HIV-positive MSM with HPV genotype data analyzed according to cytological status as far as we know. The information gained from this study can help with the design of anal cancer prevention strategies in HIV-positive patients.
机译：需要了解具有乳癌风险的人群中人乳头瘤病毒（HPV）类型的分布。在这里，我们描述了根据地理来源，年龄和性别，在与男性发生性行为（MSM）的艾滋病毒阳性男性的一个大型西班牙队列（西班牙艾滋病研究网络HPV [CoRIS-HPV]队列）中的肛门HPV基因型分布。细胞学状态。对来自1,439例HIV感染的MSM（2007年至2012年）的基线数据进行了横断面分析。使用线性阵列HPV基因分型测试进行肛门HPV基因分型。对受试者特征，患病率和95％置信区间（CI）进行描述性分析。 HPV，高危HPV（HR-HPV）和低危HPV（LR-HPV）类型的全球患病率分别为95.8％，83.0％和72.7％。在HR-HPV类型中，HPV16最常见，其次是HPV59，-39，-51，-18和-52。多种HR-HPV感染的患病率为58.5％。对于大多数HPV类型，西班牙和拉丁美洲MSM的粗略分析没有差异，并且在30岁左右的患者中发现大多数HPV类型的患病率达到峰值。在全球范围内，按特定的HPV组，肛门细胞学异常的男性比正常细胞学的男性感染率更高。据我们所知，这项研究具有根据细胞学状况分析的HPV基因型数据最多的HIV阳性MSM。从这项研究中获得的信息可以帮助设计HIV阳性患者的肛门癌预防策略。

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