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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Identification and Antifungal Susceptibility Testing of Clinical Isolates of the Candida rugosa Species Complex and Proposal of the New Species Candida neorugosa
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Molecular Identification and Antifungal Susceptibility Testing of Clinical Isolates of the Candida rugosa Species Complex and Proposal of the New Species Candida neorugosa

机译：皱念珠菌种群临床分离物的分子鉴定和抗真菌药性试验及新物种念珠菌的提议

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摘要

Candida rugosa is a poorly known fungal species occasionally involved in human infections. A molecular analysis of the sequences of the D1/D2 domains and the internal transcribed spacer (ITS) region of the ribosomal genes of 24 clinical isolates phenotypically identified as C. rugosa demonstrated that only 10 (41.6%) isolates belonged to that species. The other isolates were identified as Candida pararugosa (41.6%) and Candida pseudorugosa (8.3%). The remaining two isolates, from human and equine infections, respectively, were clearly different from the others and represent a new species proposed here as Candida neorugosa. The closest species by D1/D2 sequences was the type strain of C. rugosa, with only 92.3% similarity. C. neorugosa can also be differentiated from all other species of the C. rugosa complex by phenotypic features. The eight antifungal drugs tested showed high in vitro activity against the 24 isolates included in the study.
机译：皱皮念珠菌是一种鲜为人知的真菌物种，偶尔与人类感染有关。对表型鉴定为皱纹梭菌的24个临床分离株的核糖体基因的D1 / D2结构域和内部转录间隔区（ITS）区域进行分子分析，结果表明只有10个（41.6％）分离株属于该物种。其他分离株被鉴定为副假丝酵母（41.6％）和假假丝酵母（8.3％）。其余两个分别来自人和马感染的分离株与其他分离株明显不同，代表了此处提出的新物种假丝酵母。 D1 / D2序列最接近的物种是皱纹念珠菌的类型菌株，仅具有92.3％的相似性。也可以通过表型特征将新皱叶隐孢子虫与皱叶隐孢子虫复合物的所有其他物种区分开。测试的八种抗真菌药物对研究中包含的24种分离物表现出很高的体外活性。

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