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首页> 外文期刊>Journal of Clinical Microbiology >Serotype 5 Pneumococci Causing Invasive Pneumococcal Disease Outbreaks in Barcelona, Spain (1997 to 2011)
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Serotype 5 Pneumococci Causing Invasive Pneumococcal Disease Outbreaks in Barcelona, Spain (1997 to 2011)

机译：造成西班牙巴塞罗那侵袭性肺炎球菌疾病暴发的血清型5肺炎球菌（1997年至2011年）

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In this study, we analyzed the clinical and molecular epidemiology of invasive serotype 5 (Ser5) pneumococcal isolates in four teaching hospitals in the Barcelona, Spain, area (from 1997 to 2011). Among 5,093 invasive pneumococcal isolates collected, 134 (2.6%) Ser5 isolates were detected. Although the overall incidence of Ser5-related invasive pneumococcal disease (IPD) was low (0.25 cases/100,000 inhabitants), three incidence peaks were detected: 0.63/100,000 in 1999, 1.15/100,000 in 2005, and 0.37/100,000 in 2009. The rates of Ser5 IPD were higher among young adults (18 to 64 years old) and older adults (>64 years old) in the first two peaks, whereas they were higher among children in 2009. The majority (88.8%) of the patients presented with pneumonia. Comorbid conditions were present in young adults (47.6%) and older adults (78.7%), the most common comorbid conditions being chronic obstructive pulmonary disease (20.6% and 38.3%, respectively) and cardiovascular diseases (11.1% and 38.3%, respectively). The mortality rates were higher among older adults (8.5%). All Ser5 pneumococci tested were fully susceptible to penicillin, cefotaxime, erythromycin, and ciprofloxacin. The resistance rates were 48.5% for co-trimoxazole, 6.7% for chloramphenicol, and 6% for tetracycline. Two major related sequence types (STs), ST1223 (n = 65) and ST289 (n = 61), were detected. The Colombia5-ST289 clone was responsible for all the cases in the Ser5 outbreak in 1999, whereas the ST1223 clone accounted for 73.8% and 61.5% of the isolates in 2005 and 2009, respectively. Ser5 pneumococci are a frequent cause of IPD outbreaks in the community and involve children and adults with or without comorbidities. The implementation of the new pneumococcal conjugated vaccines (PCV10 and PCV13) might prevent such outbreaks.
机译：在这项研究中，我们分析了西班牙巴塞罗那地区（从1997年至2011年）的四家教学医院中侵袭性血清型5（Ser5）肺炎球菌分离株的临床和分子流行病学。在收集的5093例侵袭性肺炎球菌分离物中，检测到134种（2.6％）Ser5分离株。尽管与Ser5相关的侵袭性肺炎球菌疾病（IPD）的总发病率较低（0.25例/ 100,000居民），但检测到三个发病高峰：1999年为0.63 / 100,000，2005年为1.15 / 100,000，2009年为0.37 / 100,000。在前两个峰值中，年轻人（18至64岁）和老年人（> 64岁）中Ser5 IPD的发生率较高，而在2009年儿童中则较高。大多数患者（88.8％）出现与肺炎。年轻人（47.6％）和老年人（78.7％）存在合并症，最常见的合并症是慢性阻塞性肺疾病（分别为20.6％和38.3％）和心血管疾病（分别为11.1％和38.3％） 。老年人的死亡率较高（8.5％）。所有测试的Ser5肺炎球菌对青霉素，头孢噻肟，红霉素和环丙沙星完全敏感。复方新诺明的耐药率为48.5％，氯霉素为6.7％，四环素为6％。检测到两个主要的相关序列类型（ST），即ST1223（ n = 65）和ST289（ n = 61）。哥伦比亚 5 -ST289克隆导致了1999年Ser5爆发的所有病例，而ST1223克隆分别占2005年和2009年分离株的73.8％和61.5％。 Ser5肺炎球菌是社区内IPD暴发的常见原因，涉及有或没有合并症的儿童和成人。新的肺炎球菌结合疫苗（PCV10和PCV13）的实施可能会阻止此类爆发。

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