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首页> 外文期刊>Journal of Clinical Microbiology >Propionibacterium acnes and Staphylococcus lugdunensis Cause Pyogenic Osteomyelitis in an Intramedullary Nail Model in Rabbits
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Propionibacterium acnes and Staphylococcus lugdunensis Cause Pyogenic Osteomyelitis in an Intramedullary Nail Model in Rabbits

机译：痤疮丙酸杆菌和卢贡葡萄球菌在兔髓内钉模型中引起化脓性骨髓炎

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Propionibacterium acnes and coagulase-negative staphylococci (CoNS) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. The purpose of this study was to determine whether P. acnes and the CoNS species Staphylococcus lugdunensis, isolated from an “aseptically failed” prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rabbits in the absence of wear debris from the implant material. The histological features of P. acnes infection in the in vivo rabbit model were consistent with localized pyogenic osteomyelitis, and a biofilm was present on all explanted intramedullary (IM) nails. The animals displayed no outward signs of infection, such as swelling, lameness, weight loss, or elevated white blood cell count. In contrast, infection with S. lugdunensis resulted in histological features consistent with both pyogenic osteomyelitis and septic arthritis, and all S. lugdunensis-infected animals displayed weight loss and an elevated white blood cell count despite biofilm detection in only two out of six rabbits. The differences in the histological and bacteriological profiles of the two species in this rabbit model of infection are reflective of their different clinical presentations: low-grade infection in the case of P. acnes and acute infection for S. lugdunensis. These results are especially important in light of the growing recognition of chronic P. acnes biofilm infections in prosthetic joint failure and nonunion of fracture fixations, which may be currently reported as “aseptic” failure.
机译：痤疮丙酸杆菌和凝固酶阴性葡萄球菌（CoNS）是与假体关节和骨折固定装置相关感染相关的机会病原体。本研究的目的是确定分别从“无菌性衰竭”假体髋关节和联合髓内钉固定的胫骨骨折中分离出来的痤疮丙酸杆菌和CoNS种葡萄球菌是否会导致与已建立的植入物相关的骨髓炎没有植入材料产生的磨损碎片的兔骨髓炎模型。在体内兔模型中，痤疮丙酸杆菌感染的组织学特征与局部化脓性骨髓炎一致，并且所有已植入的髓内（IM）指甲上均存在生物膜。动物没有表现出感染的外在迹象，例如肿胀，la行，体重减轻或白细胞计数升高。相反，感染卢格顿酵母的组织学特征与化脓性骨髓炎和败血性关节炎相一致，尽管六只兔中有两只发现了生物膜，但感染链球菌的所有动物均表现出体重减轻和白细胞计数升高。在这种兔子感染模型中，这两种物种的组织学和细菌学特征的差异反映了它们的不同临床表现：痤疮丙酸杆菌为低度感染，而卢格敦菌为急性感染。鉴于人们越来越认识到慢性痤疮丙酸杆菌生物膜感染在人工关节衰竭和骨折固定术不愈合方面的认识日益增加，目前这些骨折可能被报告为“无菌”衰竭。

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