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首页> 外文期刊>Journal of Clinical Microbiology >Characteristics of Patients Recently Infected with HIV-1 Non-B Subtypes in France: a Nested Study within the Mandatory Notification System for New HIV Diagnoses
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Characteristics of Patients Recently Infected with HIV-1 Non-B Subtypes in France: a Nested Study within the Mandatory Notification System for New HIV Diagnoses

机译：法国最近感染HIV-1非B型亚型的患者的特征：强制性通知系统中针对新HIV诊断的嵌套研究

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The presence of HIV-1 non-B subtypes in Western Europe is commonly attributed to migration of individuals from non-European countries, but the possible role of domestic infections with non-B subtypes is not well investigated. The French mandatory anonymous reporting system for HIV is linked to a virological surveillance using assays for recent infection (<6 months) and serotyping. During the first semester of years 2007 to 2010, any sample corresponding to a non-B recent infection was analyzed by sequencing a 415-bp env region, followed by phylogenetic analysis and search for transmission clusters. Two hundred thirty-three recent HIV-1 infections with non-B variants were identified. They involved 5 subtypes and 7 circulating recombinant forms (CRFs). Ninety-two cases (39.5%) were due to heterosexual transmissions, of which 39 occurred in patients born in France. Eighty-five cases (36.5%) were identified in men having sex with men (MSM). Forty-three recent non-B infections (18.5%) segregated into 14 clusters, MSM being involved in 11 of them. Clustered transmission events included 2 to 7 cases per cluster. The largest cluster involved MSM infected by a CRF02_AG variant. In conclusion, we found that the spread of non-B subtypes in France occurs in individuals of French origin and that MSM are particularly involved in this dynamic.
机译：在西欧，HIV-1非B亚型的存在通常归因于个人从非欧洲国家的迁徙，但尚未很好地研究非B亚型家庭感染的可能作用。法国的艾滋病毒强制性匿名举报系统与病毒监测相联系，该监测使用最近感染（<6个月）和血清分型的检测方法。在2007年至2010年的第一学期中，通过对415 bp的 env 区域进行测序，然后进行系统发育分析并寻找传播簇，来分析与非B最近感染相对应的任何样品。已鉴定出233例非B型变异的最近HIV-1感染。他们涉及5个亚型和7个循环重组形式（CRF）。有92例（39.5％）是由于异性传播所致，其中39例发生在法国出生的患者中。在与男性发生性关系（MSM）的男性中鉴定出85例（36.5％）。最近有43例非B感染（占18.5％）分为14个簇，其中MSM参与了11个。集群传播事件包括每个集群2到7个案例。最大的群集涉及被CRF02_AG变体感染的MSM。总之，我们发现非B亚型在法国的扩散发生在法国血统的个体中，MSM特别参与了这种动态。

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