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首页> 外文期刊>Journal of Clinical Microbiology >Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3
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Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3

机译：人类乳头瘤病毒31 DNA负荷与宫颈上皮内瘤变2和3级风险的关系

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The association between human papillomavirus 31 (HPV31) DNA loads and the risk of cervical intraepithelial neoplasia grades 2 and 3 (CIN2–3) was evaluated among women enrolled in the atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) triage study (ALTS), who were monitored semiannually over 2 years and who had HPV31 infections detected at ≥1 visit. HPV31 DNA loads in the first HPV31-positive samples and in a random set of the last positive samples from women with ≥2 HPV31-positive visits were measured by a real-time PCR assay. CIN2–3 was histologically confirmed at the same time as the first detection of HPV31 for 88 (16.6%) of 530 women. After adjustment for HPV31 lineages, coinfection with other oncogenic types, and the timing of the first positive detection, the odds ratio (OR) per 1-log-unit increase in viral loads for the risk of a concurrent diagnosis of CIN2–3 was 1.5 (95% confidence interval [CI], 1.2 to 1.9). Of 373 women without CIN2–3 at the first positive visit who had ≥1 later visit, 44 had subsequent diagnoses of CIN2–3. The initial viral loads were associated with CIN2–3 diagnosed within 6 months after the first positive visit (adjusted OR, 1.5 [95% CI, 1.0 to 2.4]) but were unrelated to CIN2–3 diagnosed later. For a random set of 49 women who were tested for viral loads at the first and last positive visits, changes in viral loads were upward and downward among women with and without follow-up CIN2–3 diagnoses, respectively, although the difference was not statistically significant. Results suggest that HPV31 DNA load levels at the first positive visit signal a short-term but not long-term risk of CIN2–3.
机译：在未明确意义的非典型鳞状细胞（ASCUS）和低度鳞状上皮内病变的女性中评估了人类乳头瘤病毒31（HPV31）DNA负荷与宫颈上皮内瘤变2和3级（CIN2-3）的风险之间的关系。 （LSIL）分流研究（ALTS），每两年进行一次半年监测，并且在≥1次就诊时发现HPV31感染。通过实时PCR测定法对来自≥2个HPV31阳性就诊女性的第一批HPV31阳性样本和随机的最后一批阳性样本中的HPV31 DNA负荷进行了测量。在530例女性中，有88例（16.6％）首次检测到HPV31时，同时在组织学上证实了CIN2-3。在调整了HPV31谱系，与其他致癌类型的共感染以及首次阳性检测的时间之后，病毒载量每增加1个对数单位的比值比（OR）为1.5，可同时诊断CIN2–3 （95％置信区间[CI]为1.2到1.9）。在第一次阳性访视的373例女性中，首次访视无CIN2–3且以后访视≥1的女性中，有44例随后被诊断为CIN2–3。最初的病毒载量与首次阳性就诊后6个月内诊断出的CIN2–3相关（校正OR，1.5 [95％CI，1.0至2.4]），但与后来诊断出的CIN2–3无关。对于随机分组的49位在首次和最后一次阳性就诊时接受病毒载量检测的妇女，无论是否进行了CIN2–3随访诊断，妇女的病毒载量变化分别为向上和向下，尽管差异无统计学意义重大。结果表明，第一次阳性访视时HPV31 DNA负荷水平表明CIN2-3的短期而非长期危险。

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