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Advances in Laboratory Methods for Detection and Typing of Norovirus

机译:诺如病毒检测和分型的实验室方法研究进展

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Human noroviruses are the leading cause of epidemic and sporadic gastroenteritis across all age groups. Although the disease is usually self-limiting, in the United States norovirus gastroenteritis causes an estimated 56,000 to 71,000 hospitalizations and 570 to 800 deaths each year. This minireview describes the latest data on laboratory methods (molecular, immunological) for norovirus detection, including real-time reverse transcription-quantitative PCR (RT-qPCR) and commercially available immunological assays as well as the latest FDA-cleared multi-gastrointestinal-pathogen platforms. In addition, an overview is provided on the latest nomenclature and molecular epidemiology of human noroviruses.
机译:人类诺如病毒是所有年龄段流行和偶发性肠胃炎的主要原因。尽管该疾病通常是自限性的,但在美国,诺如病毒胃肠炎每年估计导致56,000至71,000人住院和570至800人死亡。这份小型回顾介绍了用于诺如病毒检测的实验室方法(分子,免疫学)的最新数据,包括实时逆转录定量PCR(RT-qPCR)和可商购的免疫学检测方法,以及最新的FDA批准的多消化道病原体平台。此外,还概述了人类诺如病毒的最新命名法和分子流行病学。

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