• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Microbiology >Rapid Antimicrobial Susceptibility Testing of Bacillus anthracis, Yersinia pestis, and Burkholderia pseudomallei by Use of Laser Light Scattering Technology
【24h】

Rapid Antimicrobial Susceptibility Testing of Bacillus anthracis, Yersinia pestis, and Burkholderia pseudomallei by Use of Laser Light Scattering Technology

机译：利用激光散射技术对炭疽芽孢杆菌，鼠疫耶尔森菌和假伯克霍尔德氏菌进行快速药敏试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rapid methods to determine antimicrobial susceptibility would assist in the timely distribution of effective treatment or postexposure prophylaxis in the aftermath of the release of bacterial biothreat agents such as Bacillus anthracis, Yersinia pestis, or Burkholderia pseudomallei. Conventional susceptibility tests require 16 to 48 h of incubation, depending on the bacterial species. We evaluated a method that is based on laser light scattering technology that measures cell density in real time. We determined that it has the ability to rapidly differentiate between growth (resistant) and no growth (susceptible) of several bacterial threat agents in the presence of clinically relevant antimicrobials. Results were available in <4 h for B. anthracis and <6 h for Y. pestis and B. pseudomallei. One exception was B. pseudomallei in the presence of ceftazidime, which required >10 h of incubation. Use of laser scattering technology decreased the time required to determine antimicrobial susceptibility by 50% to 75% for B. anthracis, Y. pestis, and B. pseudomallei compared to conventional methods.
机译：确定抗菌药敏感性的快速方法将有助于在释放细菌性生物威胁剂（如炭疽芽孢杆菌，鼠疫耶尔森氏菌或假伯克霍尔德氏菌）后及时分配有效治疗或暴露后预防措施。常规药敏试验需要孵育16至48小时，具体取决于细菌种类。我们评估了一种基于激光散射技术的方法，该方法可以实时测量细胞密度。我们确定了它具有在临床相关抗微生物剂存在下快速区分几种细菌威胁剂的生长（耐药）和无生长（易感）的能力。炭疽芽孢杆菌在＜4小时内得到结果，而鼠疫耶尔森菌和假芽孢杆菌在＜6小时内得到结果。一个例外是在头孢他啶存在下的假芽孢杆菌，需要孵育> 10小时。与传统方法相比，使用激光散射技术将炭疽芽孢杆菌，鼠疫耶尔森菌和假芽孢杆菌的确定抗菌药敏感性所需的时间减少了50％至75％。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号