Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing

Peter M. Kinnevey; Anna C. Shore; Micheál Mac Aogáin; Eilish Creamer; Gráinne I. Brennan; Hilary Humphreys; Thomas R. Rogers; Brian OConnell; David C. Coleman

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Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing

机译：通过使用全基因组测序在患者和环境部位之间加强对地方性序列22型耐甲氧西林金黄色葡萄球菌金黄色葡萄球菌的医院内传播的追踪

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Whole-genome sequencing (WGS) of 41 patient and environmental sequence type 22 methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type IV (ST22-MRSA-IV) isolates recovered over 6 weeks in one acute hospital ward in Dublin, Ireland, where ST22-MRSA IV is endemic, revealed 228 pairwise combinations differing by <40 single nucleotide variants corresponding to potential cross-transmission events (CTEs). In contrast, 15 pairwise combinations of isolates representing five CTEs were previously identified by conventional molecular epidemiological typing. WGS enhanced ST22-MRSA-IV tracking and highlighted potential transmission of MRSA via the hospital environment.

机译：在一个急性医院病房中经过6周恢复的41例患者的全基因组测序（WGS）和环境序列22型耐甲氧西林金黄色葡萄球菌葡萄球菌盒式染色体 mec IV型（ST22-MRSA-IV）分离株在爱尔兰都柏林（ST22-MRSA IV地方病）的研究中，发现228个成对组合，相差小于40个单核苷酸变体，对应于潜在的交叉传输事件（CTE）。相反，先前通过常规分子流行病学分型鉴定了代表5个CTE的15对分离株的成对组合。 WGS增强了ST22-MRSA-IV跟踪功能，并强调了MRSA通过医院环境的潜在传播。 展开▼

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《Journal of Clinical Microbiology》 |2016年第2期|共4页

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Peter M. Kinnevey; Anna C. Shore; Micheál Mac Aogáin; Eilish Creamer; Gráinne I. Brennan; Hilary Humphreys; Thomas R. Rogers; Brian OConnell; David C. Coleman;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant Staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCC M1 composite islands [J] . ShoreA.C., BrennanO.M., DeasyE.C., Antimicrobial agents and chemotherapy. . 2012,第10期

机译：医院耐甲氧西林金黄色葡萄球菌分离株的多种收集物的DNA微阵列分析将大多数分配给正确的序列类型和葡萄球菌盒型染色体mec（SCCmec）类型，并导致随后的鉴定和鉴定新的SCCmec-SCC M1复合岛

2. Prevalence of SCCmec Type IV in Nosocomial Bloodstream Isolates of Methicillin-Resistant Staphylococcus aureus [J] . Priscila de A. Trindade, Renata L. Pacheco, Silvia F. Costa, Journal of Clinical Microbiology . 2005,第7期

机译：耐甲氧西林金黄色葡萄球菌医院血分离物中IV型SCCmec的患病率

3. First Report of cfr-Carrying Plasmids in the Pandemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type IV Clone [J] . Shore Anna C., Lazaris Alexandros, Kinnevey Peter M., Antimicrobial agents and chemotherapy. . 2016,第5期

机译：大流行序列中耐甲氧西林金黄色葡萄球菌金黄色葡萄球菌盒式染色体mec IV型克隆的cfr携带质粒的首次报道

4. Repetitive-DNA-Sequence-based fingerprinting for characterizing isolates of methicillin-resistant staphylococcus aureus in aburen unit [C] . Li Jie, Xiuhua, Zeng Haitao 7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai . 2000

机译：基于重复DNA序列的指纹图谱，用于表征阿布林单元中耐甲氧西林金黄色葡萄球菌的分离株

5. Characterization of community-acquired methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis, multilocus sequence typing, and Staphylococcal protein A sequencing: Establishing a strain typing database. [D] . Roberts, Jill Carolyne. 2006

机译：通过脉冲场凝胶电泳，多基因座序列分型和葡萄球菌蛋白A测序表征社区获得的耐甲氧西林金黄色葡萄球菌：建立菌株分型数据库。

6. Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing [O] . Peter M. Kinnevey, Anna C. Shore, Micheál Mac Aogáin, 2016

机译：通过使用全基因组测序在患者和环境场所中加强对地方性序列22型耐甲氧西林金黄色葡萄球菌金黄色葡萄球菌的医院内传播的追踪

7. The recent emergence in hospitals of multidrug-resistant community-associated sequence type 1 and spa type t127 methicillin-resistant Staphylococcus aureus investigated by whole-genome sequencing: Implications for screening. [O] . Megan R Earls, Peter M Kinnevey, Gráinne I Brennan, 2017

机译：最近在医院出现了多药耐药的社区相关序列1型和spa型t127耐甲氧西林金黄色葡萄球菌通过全基因组测序研究：筛选的意义。

1. 定植压力与耐甲氧西林金黄色葡萄球菌医院内交叉传播相关性研究 [J] . 王俊瑞 ,向茜 ,尚欣荣 . 中华检验医学杂志 . 2010,第010期

2. 创伤患者医院内感染耐甲氧西林金黄色葡萄球菌毒力基因分析 [J] . 黄支密 ,糜家睿 ,罗雪平 . 医学研究杂志 . 2016,第002期

3. 住院患者与医院环境中耐甲氧西林金黄色葡萄球菌PFGE分子分型研究 [J] . 杨峰 ,吴毅凌 ,杨丽华 . 老年医学与保健 . 2018,第002期

4. 医院环境与住院患者耐甲氧西林金黄色葡萄球菌耐药性 [J] . 吴安华 ,李春辉 . 中国医学科学院学报 . 2008,第005期

5. 实时三维斑点追踪成像评价2型糖尿病患者左室功能与升主动脉弹性之间的关系 [J] . 宋香廷 ,范莉 ,芮逸飞 . 临床超声医学杂志 . 2019,第011期

1. SEQUENCES FOR DETECTION AND IDENTIFICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) OF MREJ TYPE XXI [P] . 外国专利： EP3936620A1 . 2022-01-12

机译：MREJ型XXI型耐甲氧脲耐金葡萄球菌（MRSA）的检测和鉴定序列

2. SEQUENCES FOR DETECTION AND IDENTIFICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) OF MREJ TYPE XXI [P] . 外国专利： EP2834375B1 . 2021-05-05

机译：MREJ型XXI型耐甲氧脲耐金葡萄球菌（MRSA）的检测和鉴定序列

3. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xx [P] . 外国专利： EP2325647B1 . 2021-07-14

机译：MREJ型XX型耐甲氧脲耐金黄色葡萄球菌（MRSA）的检测和鉴定序列

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Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing

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