...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Microbiology >Improved Diagnosis of Infection Associated with Osteosynthesis by Use of Sonication of Fracture Fixation Implants
【24h】

Improved Diagnosis of Infection Associated with Osteosynthesis by Use of Sonication of Fracture Fixation Implants

机译：通过使用骨折固定植入物的超声处理改善与骨合成相关的感染的诊断

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies have shown that sonication fluid cultures from removed orthopedic devices improved the microbiological diagnosis of orthopedic implant-associated infections; however, few of these investigations have applied sonication to the removed fracture fixation devices to evaluate its utility for the diagnosis of osteosynthesis-associated infection (OAI). We compared sonication fluid to conventional tissue cultures from 180 subjects with different sizes of plates and screws (n = 156), spinal implants (n = 26), and intramedullary nails (n = 3), of whom 125 and 55 subjects had OAI and noninfected osteosynthesis (NIO), respectively. The sensitivity for detecting OAI was 90.4% for sonication fluid culture and 56.8% for periprosthetic tissue cultures (P < 0.05), and the specificities were 90.9% and 96.4%, respectively. Sonication fluid culture detected more pathogens than peri-implant tissue culture (113 versus 71; P < 0.001), while polymicrobial infections were diagnosed by sonication fluid cultures and tissue cultures in 20.8% and 8% (P < 0.001), respectively. Microbiological diagnosis was achieved exclusively by sonication fluid cultures for 47 (90.4%) subjects, and among them, 18 (38.3%) had previously received antibiotics, whereas in five (9.6%) infected subjects, tissue culture was positive and the sonication fluid culture was negative. Among 39 (31.2%) OAI cases receiving antibiotics, the identification of the organisms occurred in 38.5% and 82.1% of the tissue and sonication fluid cultures, respectively (P < 0.049). We demonstrated that sonication fluid culture from removed osteosyntheses has the potential for improving the microbiological diagnosis of OAI.
机译：先前的研究表明，从去除的骨科设备中进行超声处理的液体培养可以改善骨科植入物相关感染的微生物学诊断。然而，这些研究中很少有将超声处理应用于已拆除的骨折固定装置，以评估其在诊断与骨合成相关感染（OAI）中的效用。我们将超声处理液与来自180名不同大小的板和螺钉（ n = 156），脊柱植入物（ n = 26）和髓内钉（ n = 3），其中分别有125名和55名受试者患有OAI和未感染的骨合成（NIO）。超声液体培养检测OAI的灵敏度为90.4％，假体周围组织培养检测OAI的灵敏度为56.8％（ P <0.05），特异性分别为90.9％和96.4％。超声液体培养比病原体周围组织培养检测到更多的病原体（113比71; P <0.001），而通过超声液体培养和组织培养诊断出的微生物感染率分别为20.8％和8％（ P <0.001）。仅通过超声液体培养对47名（90.4％）受试者进行了微生物学诊断，其中18名（38.3％）以前曾接受过抗生素，而在5名（9.6％）感染受试者中，组织培养呈阳性，超声液体培养是负面的。在39例（31.2％）接受抗生素治疗的OAI病例中，分别在38.5％和82.1％的组织和超声液体培养物中鉴定出了这种生物（ P <0.049）。我们证明了从去除的骨合成超声处理液体培养物具有改善OAI的微生物学诊断的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号