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首页> 外文期刊>Journal of Clinical Microbiology >Genetic Diversity and Dynamic Distribution of Mycobacterium tuberculosis Isolates Causing Pulmonary and Extrapulmonary Tuberculosis in Thailand
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Genetic Diversity and Dynamic Distribution of Mycobacterium tuberculosis Isolates Causing Pulmonary and Extrapulmonary Tuberculosis in Thailand

机译：泰国引起肺结核和肺外结核的结核分枝杆菌分离株的遗传多样性和动态分布

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This study examined the genetic diversity and dynamicity of circulating Mycobacterium tuberculosis strains in Thailand using nearly neutral molecular markers. The single nucleotide polymorphism (SNP)-based genotypes of 1,414 culture-positive M. tuberculosis isolates from 1,282 pulmonary tuberculosis (PTB) and 132 extrapulmonary TB (EPTB) patients collected from 1995 to 2011 were characterized. Among the eight SNP cluster groups (SCG), SCG2 (44.1%), which included the Beijing (BJ) genotype, and SCG1 (39.4%), an East African Indian genotype, were dominant. Comparisons between the genotypes of M. tuberculosis isolates causing PTB and EPTB in HIV-negative cases revealed similar prevalence trends although genetic diversity was higher in the PTB patients. The identification of 10 reported sequence types (STs) and three novel STs was hypothesized to indicate preferential expansion of the SCG2 genotype, especially the modern BJ ST10 (15.6%) and ancestral BJ ST19 (13.1%). An association between SCG2 and SCG1 genotypes and particular patient age groups implies the existence of different genetic advantages among the bacterial populations. The results revealed that increasing numbers of young patients were infected with M. tuberculosis SCGs 2 and 5, which contrasts with the reduction of the SCG1 genotype. Our results indicate the selection and dissemination of potent M. tuberculosis genotypes in this population. The determination of heterogeneity and dynamic population changes of circulating M. tuberculosis strains in countries using the Mycobacterium bovis BCG (bacillus Calmette-Guérin) vaccine are beneficial for vaccine development and control strategies.
机译：这项研究使用近乎中性的分子标记检查了泰国循环结核分枝杆菌菌株的遗传多样性和动态。从1995年至2011年收集的1,282例肺结核分支杆菌和1,282例肺结核分支杆菌（PTB）和132例肺外结核（EPTB）患者的1,414例培养阳性结核分枝杆菌的基于单核苷酸多态性（SNP）的基因型进行了表征。在八个SNP集群组（SCG）中，占主导地位的是北京（BJ）基因型的SCG2（44.1％），以及东非印度裔基因型的SCG1（39.4％）。在HIV阴性病例中，引起PTB和EPTB的结核分枝杆菌菌株的基因型之间的比较显示了相似的流行趋势，尽管PTB患者的遗传多样性更高。假设鉴定出10个报道的序列类型（ST）和三个新的ST，以表明SCG2基因型的优先扩展，尤其是现代BJ ST10（15.6％）和祖先BJ ST19（13.1％）。 SCG2和SCG1基因型与特定患者年龄组之间的关联暗示细菌种群之间存在不同的遗传优势。结果表明，越来越多的年轻患者感染了结核分枝杆菌SCG 2和5，这与SCG1基因型的减少形成了对比。我们的结果表明该人群中有效的结核分枝杆菌基因型的选择和传播。使用牛分枝杆菌卡介苗（卡介苗-Guérin杆菌）疫苗测定国家中正在传播的结核分枝杆菌菌株的异质性和动态种群变化，对疫苗的开发和控制策略是有益的。

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