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首页> 外文期刊>Journal of Clinical Microbiology >T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples
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T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples

机译：基于T2磁共振检测的全血样品中三种与莱姆病相关的疏螺旋体物种的直接检测

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Lyme disease (LD) is a tick-borne infection caused by pathogenic spirochetes of the Borrelia burgdorferi sensu lato genospecies. B. burgdorferi sensu stricto has been identified as the main causative agent in North America, accounting for 20,000 to 30,000 confirmed cases annually reported to the Centers for Disease Control (CDC) in the United States (http://www.cdc.gov/lyme/stats/chartstables/casesbyyear.html). However, estimates indicate that there may be closer to 300,000 new cases yearly (1–3). In addition to B. burgdorferi sensu stricto, LD in Europe is also caused by B. afzelii and B. garinii, with an estimated 60,000 to 90,000 cases per year (4). Other Borrelia species can cause LD, including, but not limited to, B. bavariensis, B. bisettii, and B. lusitainiae, although these species represent a minority of cases (5–7) Recently, B. mayonii was discovered to be a distinct species from B. burgdorferi causing LD in the upper Midwest of the United States and may represent an emerging causative agent of LD in the United States (8). Early LD is variably characterized by the presence of an erythema migrans (EM) rash and flu-like symptoms, including fever, fatigue, and myalgia (9, 10). If left untreated, later-stage manifestations, such as arthritis, carditis, or neuroborreliosis, may develop (10), underscoring the necessity for early detection and treatment.
机译：莱姆病（LD）是由博氏疏螺旋体基因组种的致病性螺旋体引起的tick传播感染。在北美，B。burgdorferi sensustricto被确定为主要病原体，每年向美国疾病控制中心（CDC）报告的确诊病例为20,000至30,000（http://www.cdc.gov/ lyme / stats / chartstables / casesbyyear.html）。但是，估计表明，每年可能会有近300,000例新病例（1-3）。在欧洲，除了burgdorferi sensu stricto之外，LD也是由afzelii和B. garinii引起的，估计每年有60,000至90,000例（4）。其他的疏螺旋体物种也可能引起LD，包括但不限于巴氏芽孢杆菌，双歧杆菌和lusitainiae，尽管这些物种仅占少数病例（5-7）。 B. burgdorferi的不同物种在美国中西部地区引起LD，并且可能代表了美国LD的新兴病原体（8）。早期LD的特征是存在红斑偏头痛（EM）皮疹和类似流感的症状，包括发烧，疲劳和肌痛（9，10）。如果不及时治疗，可能会发展出后期症状，例如关节炎，心脏病或神经性硼尿病（10），这强调了早期发现和治疗的必要性。

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