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首页> 外文期刊>Journal of Clinical Microbiology >Epidemiology of Invasive Group A Streptococcal Disease in Alaska, 2001 to 2013
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Epidemiology of Invasive Group A Streptococcal Disease in Alaska, 2001 to 2013

机译:2001年至2013年阿拉斯加A级侵入性链球菌疾病的流行病学

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The Arctic Investigations Program (AIP) began surveillance for invasive group A streptococcal (GAS) infections in Alaska in 2000 as part of the invasive bacterial diseases population-based laboratory surveillance program. Between 2001 and 2013, there were 516 cases of GAS infection reported, for an overall annual incidence of 5.8 cases per 100,000 persons with 56 deaths (case fatality rate, 10.7%). Of the 516 confirmed cases of invasive GAS infection, 422 (82%) had isolates available for laboratory analysis. All isolates were susceptible to penicillin, cefotaxime, and levofloxacin. Resistance to tetracycline, erythromycin, and clindamycin was seen in 11% (n = 8), 5.8% (n = 20), and 1.2% (n = 4) of the isolates, respectively. A total of 51 emm types were identified, of which emm1 (11.1%) was the most prevalent, followed by emm82 (8.8%), emm49 (7.8%), emm12 and emm3 (6.6% each), emm89 (6.2%), emm108 (5.5%), emm28 (4.7%), emm92 (4%), and emm41 (3.8%). The five most common emm types accounted for 41% of isolates. The emm types in the proposed 26-valent and 30-valent vaccines accounted for 56% and 78% of all cases, respectively. GAS remains an important cause of invasive bacterial disease in Alaska. Continued surveillance of GAS infections will help improve understanding of the epidemiology of invasive disease, with an impact on disease control, notification of outbreaks, and vaccine development.
机译:北极调查计划(AIP)于2000年开始对阿拉斯加的A组侵入性链球菌(GAS)感染进行监视,作为基于侵入性细菌疾病人群的实验室监视计划的一部分。在2001年至2013年之间,报告了516例GAS感染病例,年平均发病率为每100,000人5.8例,死亡56例(病死率,10.7%)。在确认的516例侵袭性GAS感染病例中,有422例(82%)具有可用于实验室分析的分离株。所有分离株均对青霉素,头孢噻肟和左氧氟沙星敏感。对四环素,红霉素和克林霉素的耐药性分别为11%( n = 8),5.8%( n = 20)和1.2%( n < / em> = 4)。总共鉴定出51种 emm 类型,其中 emm 1(11.1%)最普遍,其次是 emm 82(8.8% ), emm 49(7.8%), emm 12和 emm 3(各占6.6%), emm 89 (6.2%), emm 108(5.5%), emm 28(4.7%), emm 92(4%)和 emm 41(3.8%)。五个最常见的 emm 类型占分离株的41%。提议的26价和30价疫苗中的 类型分别占所有病例的56%和78%。 GAS仍然是阿拉斯加侵袭性细菌性疾病的重要原因。持续监测GAS感染将有助于增进对浸润性疾病流行病学的了解,并影响疾病控制,疫情通报和疫苗开发。

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