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首页> 外文期刊>Journal of Clinical Microbiology >Investigation of Kingella kingae Invasive Infection Outbreaks in Day Care Facilities: Assessment of a Rapid Genotyping Tool Targeting the DNA Uptake Sequence
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Investigation of Kingella kingae Invasive Infection Outbreaks in Day Care Facilities: Assessment of a Rapid Genotyping Tool Targeting the DNA Uptake Sequence

机译：日间护理机构中的金黄色小金菌侵袭性感染调查：靶向DNA吸收序列的快速基因分型工具的评估

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As a result of increasing use of improved detection methods, Kingella kingae is being increasingly recognized as an important pediatric pathogen and the most common etiology of skeletal system infections in children aged 6 to 48 months in countries where sensitive molecular diagnostic methods are routinely used for processing joint aspirates and bone exudates (1–3). The organism is carried in the oropharynx without clinical symptoms and is transmitted from child to child by close contact among siblings and playmates (4–7). The colonized mucosal surface is also the portal of entry of K. kingae to the bloodstream, from where it may invade the skeletal system and the endocardium, for which the species exhibits a particular tropism (8–10). The K. kingae strains carried differ in virulence. Some strains belonging to a few distinct genotypic clones and characterized by polysaccharide capsule a or b are responsible for the vast majority of clinical diseases (11). On the other hand, other clones that elaborate capsule type c or d are usually found as mere respiratory colonizers and are rarely isolated from invasive infections (11). The age-related prevalence of K. kingae colonization parallels that of invasive disease, reaching 10 to 12% during the second year of life and decreasing in older children (4, 5). Similarly to other pathogens of respiratory origin, the colonization rate is substantially increased among children attending day care facilities, and out-of-home care is significantly and independently associated with K. kingae carriage (6).
机译：由于越来越多地使用改进的检测方法，在通常使用敏感分子诊断方法进行治疗的国家中，金刚国王菌已被公认为重要的儿科病原体和最常见的6至48个月儿童的骨骼系统感染病因。关节抽吸和骨渗出（1-3）。该生物体在口咽中携带时没有临床症状，并且通过兄弟姐妹和玩伴之间的密切接触在儿童之间传播（4-7）。殖民化的粘膜表面也是金黄色K.进入血流的入口，从那里它可能侵入骨骼系统和心内膜，为此物种表现出特定的向性（8-10）。携带的K. kingae菌株毒力不同。一些菌株属于少数几个不同的基因型克隆，其特征是多糖荚膜a或b导致了大多数临床疾病（11）。另一方面，精心制作的c型或d型胶囊的其他克隆通常只是呼吸定居者，很少从侵袭性感染中分离出来（11）。金黄色K.菌定植与年龄相关的流行与侵入性疾病相似，在生命的第二年达到10％至12％，大龄儿童则有所下降（4、5）。与其他呼吸道病原体相似，在日托机构中的儿童中，定居率显着提高，而家庭外护理与K. kingae运输显着且独立相关（6）。

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