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首页> 外文期刊>Journal of Clinical Microbiology >Denmark14-230 Clone as an Increasing Cause of Pneumococcal Infection in Portugal within a Background of Diverse Serotype 19A Lineages
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Denmark14-230 Clone as an Increasing Cause of Pneumococcal Infection in Portugal within a Background of Diverse Serotype 19A Lineages

机译：在不同血清型19A血统的背景下，Denmark14-230克隆是葡萄牙肺炎球菌感染增加的原因

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摘要

Pneumococci of serotype 19A are increasingly found to be the cause of infection in various geographic regions. We have characterized the serotype 19A isolates (n = 288) found among pneumococci responsible for infections (n = 1,925) and pneumococci recovered from asymptomatic carriers (n = 1,973) in Portugal between 2001 and 2006. We show that despite the existence of serotype 19A clones that have a greater potential to cause invasive disease or an enhanced colonization capacity, the lineage that is increasing as a cause of infection in Portugal is a multiresistant clone that is competent at both. The expanding Denmark14-230 clone found in Portugal is disseminated in other Mediterranean countries, where it is also increasingly responsible for invasive infections in both children and adults. The lineages driving the rise of serotype 19A infections in Asia and the United States (sequence type 320 [ST320] and ST199) are either absent or account for only a small proportion of isolates in Portugal. These data highlight the importance of locally circulating clones with the ability to compete in the nasopharyngeal niche in the emergence of the serotype 19A lineages which are an increasing cause of infection in various geographic regions.
机译：越来越多地发现血清型19A的肺炎球菌是感染的原因。我们已经鉴定出在负责感染的肺炎链球菌（ n = 1,925）和从无症状携带者（ n ）中回收的肺炎球菌中发现的血清型19A分离株（ n = 288）。 em> = 1,973）在葡萄牙到2001年之间。我们显示，尽管存在19A血清型克隆，它们更有可能引起侵袭性疾病或增强定殖能力，但作为葡萄牙感染原因的血统却不断增加两者兼具的多抗性克隆。在葡萄牙发现的不断扩大的丹麦 14 -230克隆已在其他地中海国家传播，在地中海地区，它也越来越引起儿童和成人的侵袭性感染。在亚洲和美国，导致19A血清型感染上升的血统（序列类型320 [ST320]和ST199）不存在，或仅占葡萄牙分离株的一小部分。这些数据突出了在血清型19A谱系的出现中具有在鼻咽利基中竞争能力的局部循环克隆的重要性，而血清型19A谱系是在各个地理区域感染的主要原因。

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