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首页> 外文期刊>Journal of Clinical Microbiology >The Trypomastigote Small Surface Antigen from Trypanosoma cruzi Improves Treatment Evaluation and Diagnosis in Pediatric Chagas Disease
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The Trypomastigote Small Surface Antigen from Trypanosoma cruzi Improves Treatment Evaluation and Diagnosis in Pediatric Chagas Disease

机译:克氏锥虫的锥虫小表面抗原改善小儿南美锥虫病的治疗评价和诊断

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Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong disease for which no vaccines are yet available. With ~6 million people already infected and up to 70 million individuals at risk of infection, Chagas disease constitutes one of the most important parasitic diseases in Latin America and an emerging threat to global public health (1, 2). T. cruzi transmission occurs when humans are exposed to the contaminated feces of blood-sucking triatomine vectors, through the ingestion of tainted food/beverages (3), blood transfusion or organ transplantation (1) or maternal-fetal transmission (4, 5). According to epidemiological data, maternal-fetal transmission occurs in ~5% of T. cruzi-infected mothers, which leads to ~15,000 new congenital cases per year (5).
机译:由原生动物克氏锥虫引起的恰加斯病是一种终生疾病,尚无疫苗可用。恰加斯病已造成约600万人感染,有多达7000万人面临感染的危险,是拉丁美洲最重要的寄生虫病之一,并且正在威胁全球公共卫生(1、2)。当人类通过摄入污染的食物/饮料(3),输血或器官移植(1)或母婴传播(4、5)暴露于受污染的吸血三氢吗啡载体的粪便中时,就会发生克鲁氏锥虫传播。 。根据流行病学数据,在约5%的克鲁斯氏锥虫感染母亲中发生母婴传播,每年导致约15,000例新先天病例(5)。

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