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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Detection Of Human Papilloma Virus In Esophageal Squamous Cell Carcinoma In Guilan Province
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Detection Of Human Papilloma Virus In Esophageal Squamous Cell Carcinoma In Guilan Province

机译：桂兰市食管鳞癌中人乳头瘤病毒的检测

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Background: Despite many researches on the causes of Esophageal Squamous Cell Carcinoma (ESCC) many factors can cause but some types of HPV seem to be one of those factor. At the last studies the HPV cause 10 to 67% in some regions. Guilan is a region in Iran with high incidence of (ESCC) so it’s need to study more on (ESCC). Methods: In this study, we compared the prevalence of 3 kind of primers: general markers GP5+/GP6+ to show how much HPV are participated, mild oncogenic types of HPV 31,33,35,39,41,51,52 and high-risk oncogenic types of HPV 16 and 18 on E6/E7 gene in tumor tissues from 45 ESCC cases. Results: In 17 of 45 ESCC (37.7%) samples were positive for general markers ,GP5+/GP6+, the HPV presence was 4 of 45 and in respect of ESCC (8.8%) samples were positive for oncogenic types and 2 of the ESCC (4.4%) samples were high risk HPV 16,18 E6/E7 gene and the 22 samples were negative for HPV types.Conclusions: Our data are consisted with HPV DNA studies conducted in high–risk area (Guilan) for ESCC. HPV should be considered as a potential factor responsible for the increased incidence of ESCC, in spite of low incident in our study in Guilan .
机译：背景：尽管对食管鳞状细胞癌（ESCC）的病因进行了许多研究，但许多因素均可引起，但某些类型的HPV似乎是其中之一。在最近的研究中，HPV在某些地区引起10％到67％的感染。桂兰是伊朗（ESCC）高发地区，因此需要对（ESCC）进行更多研究。方法：在这项研究中，我们比较了三种引物的普遍性：通用标记GP5 + / GP6 +，以显示参与了多少HPV，轻度致癌类型的HPV 31、33、35、39、41、51、52和高在45例ESCC患者的肿瘤组织中，HPV 16和18对E6 / E7基因具有致癌性。结果：在45例ESCC中，有17例（37.7％）的常规标志物GP5 + / GP6 +阳性，HPV在45例中有4例，在ESCC（8.8％）样本中，致癌类型和2例ESCC（ 4.4％）的样本是高危HPV 16,18 E6 / E7基因，而22份样本的HPV类型呈阴性。结论：我们的数据包括在ESCC高危地区（Guilan）进行的HPV DNA研究。尽管在桂兰的研究中HPV发生率较低，但应将HPV视为导致ESCC发生率增加的潜在因素。

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