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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Effect of Vitamin C on the Erythrocyte Antioxidant Enzymes in Intoxicated-Lead Rat Offsprings
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The Effect of Vitamin C on the Erythrocyte Antioxidant Enzymes in Intoxicated-Lead Rat Offsprings

机译：维生素C对铅中毒后代大鼠红细胞抗氧化酶的影响

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Objective: Lead exposure or lead poisoning is known to cause a large spectrum of physiological, biochemical, and behavioural disorders in animals. This study was aimed at assessing the effect of vitamin C on the erythrocyte superoxide dismutase, glutathione peroxidase and the glutathione reductase activities in intoxicated- lead rat offsprings.Methods: This study was performed on the pups from female Wistar albino rats. The rats were divided into 4 groups and the treatments were administered through drinking water. Group1 (control group) consumed distilled water. Group 2 (lead group) consumed a solution of lead acetate (300mg/L). Group3 (lead + vitamin C) consumed a solution of lead (300mg/L) which was supplemented with vitamin C (2g/L). Group4 (vitamin group) consumed a solution of vitamin C (2g/L). The enzyme activities were determined in all the 4 groups.Results: The administration of lead showed a decrease in the enzyme activities. The superoxide dismutase activity was increased after the administration of lead in combination with vitamin C. The lead treated rats showed significantly lower body weights at birth and at weaning. The vitamin C treatment showed a significant increase in the body weight. The haemoglobin levels were significantly decreased in the lead-treated rats. The addition of vitamin C to the lead treatment and vitamin C alone could elevate the haemoglobin levels significantly.Conclusion: The results of this study showed that lead alterates the erythrocyte antioxidant enzyme activities. There was an increase in the superoxide dismutase activity following the treatment with vitamin C. This study suggests that the treatment with vitamin C during lactation has a therapeutic effect in the treatment of lead intoxication. The administration of vitamin C prevents haemoglobin reduction in the erythrocytes.
机译：目的：已知铅暴露或铅中毒会引起动物多种生理，生化和行为障碍。本研究旨在评估维生素C对中毒铅大鼠后代中红细胞超氧化物歧化酶，谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性的影响。方法：本研究是针对雌性Wistar白化病大鼠的幼崽进行的。将大鼠分为4组，并通过饮用水进行治疗。第一组（对照组）消耗了蒸馏水。第2组（铅组）消耗了乙酸铅溶液（300mg / L）。第3组（铅+维生素C）消耗了铅溶液（300mg / L），并补充了维生素C（2g / L）。第4组（维生素组）消耗了维生素C溶液（2g / L）。测定了所有4组的酶活性。结果：铅的施用显示酶活性降低。铅与维生素C联用后，超氧化物歧化酶活性增加。经铅处理的大鼠出生时和断奶时体重明显降低。维生素C处理显示体重显着增加。铅治疗的大鼠血红蛋白水平显着降低。铅治疗中添加维生素C和单独使用维生素C可以显着提高血红蛋白水平。结论：本研究结果表明铅改变了红细胞抗氧化酶的活性。用维生素C处理后，超氧化物歧化酶活性有所增加。这项研究表明，在哺乳期用维生素C处理对铅中毒具有治疗作用。维生素C的给药可防止血红蛋白减少。

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