Giant Sporadic Low Grade Malignant Peripheral Nerve Sheath (MPNST) of Left Thigh

Dhiraj B. Nikumbh; K.H. Suryawanshi; N.V. Dravid; T.B. Patil; C.M. Rokade

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Giant Sporadic Low Grade Malignant Peripheral Nerve Sheath (MPNST) of Left Thigh

机译：左大腿恶性散发性低度恶性周围神经鞘（MPNST）

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Malignant Peripheral Nerve Sheath Tumours (MPNST) are rare spindle- cell sarcomas which are derived from the schwann cells or the pleuripotent cells of the neural crest. MPNSTs are usually located in the peripheral nerve trunk roots, extremities and in the head and neck region. These tumours may arise as sporadic variants or in patients with neurofibromatosis1 (NF1). The estimated incidence of MPNSTs in the patients with NF1is 2-5% as compared to a 0.001% incidence in the general population. Herein, we are reporting a case of a giant sporadic (NF1 independent) low grade MPNST of the left thigh in 65 year female patient, which had a good prognosis.

机译：恶性周围神经鞘瘤（MPNST）是罕见的纺锤状细胞肉瘤，其起源于神经rest的schwann细胞或多能细胞。 MPNST通常位于周围神经干的根部，四肢和头颈部区域。这些肿瘤可能是散发性变体，也可能是神经纤维瘤病（NF1）患者。在NF1患者中，MPNSTs的估计发病率为2-5％，而在一般人群中，为0.001％。本文中，我们报道了65岁女性患者左大腿巨大的散发性（独立于NF1的）低度MPNST病例，预后良好。

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《Journal of Clinical and Diagnostic Research》 |2013年第6期|共4页
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Dhiraj B. Nikumbh; K.H. Suryawanshi; N.V. Dravid; T.B. Patil; C.M. Rokade;
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中图分类临床医学;
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1. Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST [J] . Ruoyu Miao, Haotong Wang, Alex Jacobson, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2019,第1期

机译：辐射诱导和神经纤维瘤病相关的恶性周围神经鞘瘤（MPNST）比零星MPNST更差
2. Evaluation of eight melanocytic and neural crest‐associated markers in a well‐characterised series of 124 malignant peripheral nerve sheath tumours ( MPNST MPNST ): useful to distinguish MPNST MPNST from melanoma? [J] . Gaspard Margot, Lamant Laurence, Tournier Emilie, Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2018,第6期

机译：评价八个黑素细胞和神经嵴相关标志物中的八个特征在于124个恶性周围神经鞘瘤（MPNST MPNST）：可用于区分MENST MPNST与黑色素瘤有用吗？
3. Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016) [J] . Brigitte C. Widemann, Yao Lu, Denise Reinke, Sarcoma . 2019,第1期

机译：靶向散发性和神经纤维瘤病1（NF1）相关难治性恶性周围神经鞘瘤（MPNST）在艾弗莫司与Bevacizumab组合的研究中（SARC016）
4. Melanocytic Nevi, Melanoma and Malignant Peripheral Nerve SheathTumors: Not in the Textbooks. [C] . Brian A. Summers Annual Meeting of The American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology . 2012

机译：Melanocytic Nevi，黑色素瘤和恶性周围神经护套：不在教科书中。
5. RABL6A Signaling as an Oncogenic Driver and Therapeutic Target in Malignant Peripheral Nerve Sheath Tumors (MPNST) [D] . Kohlmeyer, Jordan L. 2021

机译：Rabl6a以恶性外周神经鞘肿瘤（MPNST）为致癌驾驶员和治疗靶标
6. Giant Sporadic Low Grade Malignant Peripheral Nerve Sheath (MPNST) of Left Thigh [O] . Dhiraj B. Nikumbh, K.H. Suryawanshi, N.V. Dravid, 2013

机译：左大腿恶性散发性低度恶性周围神经鞘（MPNST）
7. Radiation Therapy in Management of Sporadic and Neurofibromatosis Type 1 (NF1) Associated Malignant Peripheral Nerve Sheath Tumors (MPNST) [O] . Jenna eKahn, Andy eGillespie, Maria eTsokos, 2014

机译：放射治疗治疗散发性和神经纤维瘤病1型（NF1）相关恶性周围神经鞘膜瘤（mpNsT）

Giant Sporadic Low Grade Malignant Peripheral Nerve Sheath (MPNST) of Left Thigh

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