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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Pathology of Lithium Induced Nephropathy: A Case Report and Review, with Emphasis on the Demonstration of Mast Cells
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The Pathology of Lithium Induced Nephropathy: A Case Report and Review, with Emphasis on the Demonstration of Mast Cells

机译：锂致肾病的病理学：一例报道并复习，并着重于肥大细胞的演示

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Lithium is a psychotropic agent which is widely employed in the psychiatric practice throughout the world. The therapeutic index of lithium is low and an acute intoxication may appear, which may lead to death or a permanent disability. A frequent side effect of lithium is renal toxicity. The collecting tubules have been identified as the site of action of lithium, due to the down regulation of Acquaporin-2. The mast cells have been associated with a wide range of human renal diseases.They have been documented to be associated with interstitial fibrosis and an impaired renal function.We are reporting a case of a 42 year old male who was admitted with a history of an ltered sensorium of short duration.He had bipolar disorder and was on lithium. Investigations revealed a severely compromised renal function. The patient?s condition worsened and he expired. A necropsy was performed. The kidneys and the lungs were subjected to a histopathological examination. The kidneys showed a significant Chronic Tubulointerstitial Nephropathy [CTIN] and a considerable glomerular pathology. Toludine blue [1%] staining demonstrated mast cells in the interstitium and the connective tissue of the renal pelvis. This appears to be the first time that mast cells were demonstrated in a case of lithium induced nephropathy in humans. It may be hypothesized that mast cells may possibly play a role in lithium induced nephropathy as a concurrent mechanism.
机译：锂是一种精神药物，在全世界的精神病学实践中广泛使用。锂的治疗指数很低，可能会出现急性中毒，从而导致死亡或永久性残疾。锂的常见副作用是肾毒性。由于Acquaporin-2的下调，收集管已被确定为锂的作用部位。肥大细胞与广泛的人类肾脏疾病有关，据报道它们与间质纤维化和肾功能受损有关。我们报道了一例42岁的男性，他的病史是感官持续时间短。他患有双相情感障碍，正在服用锂。调查显示肾脏功能严重受损。病人的病情恶化，他已经死亡。进行尸检。对肾脏和肺进行组织病理学检查。肾脏显示出严重的慢性肾小管间质性肾病[CTIN]和相当大的肾小球病理。甲苯胺蓝[1％]染色显示肾盂间质和结缔组织中有肥大细胞。这似乎是首次在锂诱导的人类肾病中证实肥大细胞。可以假设肥大细胞可能在锂诱导的肾病中作为一种并行机制起作用。

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