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首页> 外文期刊>Journal of cell biology >Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors
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Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors

机译：Pex3过氧化物酶体生物合成蛋白在过氧化物酶体遗传中起V类肌球蛋白受体的作用

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摘要

In Saccharomyces cerevisiae , peroxisomal inheritance from mother cell to bud is conducted by the class V myosin motor, Myo2p. However, homologues of S. cerevisiae Myo2p peroxisomal receptor, Inp2p, are not readily identifiable outside the Saccharomycetaceae family. Here, we demonstrate an unexpected role for Pex3 proteins in peroxisome inheritance. Both Pex3p and Pex3Bp are peroxisomal integral membrane proteins that function as peroxisomal receptors for class V myosin through direct interaction with the myosin globular tail. In cells lacking Pex3Bp, peroxisomes are preferentially retained by the mother cell, whereas most peroxisomes gather and are transferred en masse to the bud in cells overexpressing Pex3Bp or Pex3p. Our results reveal an unprecedented role for members of the Pex3 protein family in peroxisome motility and inheritance in addition to their well-established role in peroxisome biogenesis at the endoplasmic reticulum. Our results point to a temporal link between peroxisome formation and inheritance and delineate a general mechanism of peroxisome inheritance in eukaryotic cells.
机译：在酿酒酵母中，从母细胞到芽的过氧化物酶体遗传是由V类肌球蛋白马达Myo2p进行的。但是，酿酒酵母Myo2p过氧化物酶体受体Inp2p的同源物在酿酒酵母科之外不易鉴定。在这里，我们证明了Pex3蛋白在过氧化物酶体遗传中的意外作用。 Pex3p和Pex3Bp都是过氧化物酶体整合膜蛋白，可通过与肌球蛋白球状尾巴直接相互作用而充当V类肌球蛋白的过氧化物酶体受体。在缺乏Pex3Bp的细胞中，过氧化物酶体优先保留在母细胞中，而大多数过氧化物酶体在过表达Pex3Bp或Pex3p的细胞中聚集并大量转移到芽中。我们的结果揭示了Pex3蛋白家族成员在过氧化物酶体运动性和遗传中的空前作用，以及它们在内质网中过氧化物酶体生物发生中的公认作用。我们的研究结果表明过氧化物酶体形成和遗传之间的时间联系，并描绘了真核细胞中过氧化物酶体遗传的一般机制。

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