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Report of the Multiple Sclerosis Treatments in Iran (Khorasan Provinces)

机译：伊朗（霍拉桑省）的多发性硬化症治疗报告

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Multiple sclerosis (MS) is a chronic disease of the central nerve system. Iran has a medium-high prevalence of MS patients. While much is known about the beneficial and adverse treatments of MS in the world, there is a paucity of documental information about MS treatments in Iran. This study was done to provide the documentary details of MS medications. In a 6-month cross-sectional study, 248 MS patients from the Mashhad MS association in the Khorasan province were surveyed. Data was collected by employing a 32- item self-administered questionnaire in a face to face interview, which consisted of different variables. Nonparametric tests and descriptive statistical analysis were applied to assess the distribution and the effects of medication use in the population. 40% of the patients used interferonβ-1b (Betaferon), 30% used interferonβ-1a (Rebif), 14% used interferonβ-1a (Avonex), 13% used interferon β-1a (CinnoVex) [Immunomodulatory Agents (IMDs)] and 3% used Mitoxantrone (Non-IMDs). The patients? satisfaction with INF therapy in terms of, the most efficacy, the least side effect, the cost and attacks reduction was 59% for Avonex, 74% for Betaferon, 44% CinnoVex and 77% for Rebif. The most adverse effects reported by Avonex users were flulike symptoms (53%), headache (31%), tiredness and muscle-aches (16%); Betaferon: flulike symptoms (60%), injection site reactions (25%), hair loss(15%) and Rebif: headache and muscle-aches (60%), injection site reactions (30%) and menstrual disorders (10%) . There was no significant association between the side effects of INF with respect to gender, the war attendance, family history of attending in the war, BMI (p value>0.05). The only significant difference was between CinnoVex side effects with respect to gender and BMI, as a high proportion of females reported flu-like symptoms, injection site reaction and hair loss. The common method of MS treatment was the modulation of the immune system with IMDs, low-dose (Avonex-CinnoVex) for low frequency and high -dose (Betaferon-Rebif) for high frequency. The main aim of symptom therapy was to cure depression and spasticity. The least adverse effects were related to Rebif, Betaferon, and Avonex respectively. The only medicine for MS relapses was a course of high dose of Methyl prednisolone. The overall treatment pattern of MS in Iran is like that in the western countries.
机译：多发性硬化症（MS）是中枢神经系统的慢性疾病。伊朗的MS患者患病率较高。尽管全世界对MS的有益和不良治疗知之甚少，但在伊朗，有关MS治疗的文献资料很少。进行这项研究是为了提供MS药物的文献资料。在为期6个月的横断面研究中，对霍拉桑省Mashhad MS协会的248名MS患者进行了调查。通过在面对面访谈中采用32项自我管理的问卷来收集数据，该问卷由不同变量组成。采用非参数测试和描述性统计分析来评估人群中药物使用的分布和影响。 40％的患者使用干扰素β-1b（Betaferon），30％的干扰素β-1a（Rebif），14％的干扰素β-1a（Avonex），13％的干扰素β-1a（CinnoVex）[免疫调节剂（IMDs）]以及3％的米托蒽醌（Non-IMD）。病人呢就最有效，副作用最小，成本和发作减少而言，对INF治疗的满意度为Avonex 59％，Betaferon 74％，CinnoVex 44％和Rebif 77％。 Avonex使用者报告的最严重不良反应是流感样症状（53％），头痛（31％），疲倦和肌肉疼痛（16％）; Betaferon：感冒症状（60％），注射部位反应（25％），脱发（15％）和Rebif：头痛和肌肉疼痛（60％），注射部位反应（30％）和月经失调（10％） 。 INF的性别副作用，参战人数，参战家族史，BMI之间无显着相关性（p值> 0.05）。唯一的显着差异是CinnoVex在性别和BMI方面的副作用之间，因为高比例的女性报告有流感样症状，注射部位反应和脱发。 MS治疗的常见方法是使用IMD调节免疫系统，低剂量用于低频率（Avonex-CinnoVex），高剂量用于高剂量（Betaferon-Rebif）。症状疗法的主要目的是治疗抑郁症和痉挛。最少的不良反应分别与Rebif，Betaferon和Avonex有关。 MS复发的唯一药物是高剂量甲泼尼龙。在伊朗，MS的总体治疗方式与西方国家类似。

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