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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Life Threatening Lactic Acidosis Secondary To Metformin, In A Low Risk Patient
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Life Threatening Lactic Acidosis Secondary To Metformin, In A Low Risk Patient

机译：低危患者继发于二甲双胍的威胁生命的乳酸酸中毒

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A 45-year-old lady was admitted to the intensive care unit (ICU) with a two day history of persistent nausea, vomiting, abdominal pain, and shortness of breath. Her medical history was remarkable for diabetes mellitus (DM) type II on Gliclazide 80 mg twice daily, and metformin 500 mg, three times daily. On examination, the patient was tachypnic, with cold extremities. Blood chemistry showed: random blood sugar levels of 20.6 mmol/L, and blood lactate concentration levels of 9.45 mmol/L, while urine and plasma tests were negative for ketone bodies. A provisional diagnosis of metformin-induced lactic acidosis was made. Intravenous calcium gluconate, soluble insulin, and bicarbonate were given initially, and urgent haemodialysis was performed. On the following days, the level of lactic acid and potassium returned to normal. The patient made a subsequent smooth recovery, and did not require further renal support.
机译：一名45岁的女士被送入重症监护病房（ICU），有两天的持续恶心，呕吐，腹痛和呼吸急促的病史。对于II型糖尿病（DM），格列齐特80 mg每天两次，二甲双胍500 mg每天3次，她的病史非常显着。经检查，该患者呼吸急促，四肢寒冷。血液化学结果显示：随机血糖水平为20.6 mmol / L，血液乳酸浓度为9.45 mmol / L，而尿液和血浆测试对酮体呈阴性。初步诊断为二甲双胍诱发的乳酸性酸中毒。最初给予静脉葡萄糖酸钙，可溶性胰岛素和碳酸氢盐，并进行紧急血液透析。接下来的几天，乳酸和钾的含量恢复正常。病人随后恢复了平稳，不需要进一步的肾脏支持。

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