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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of the Salivary and the Serum Nitric Oxide Levels in Chronic and Aggressive Periodontitis: A Biochemical Study
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Comparison of the Salivary and the Serum Nitric Oxide Levels in Chronic and Aggressive Periodontitis: A Biochemical Study

机译：慢性和侵袭性牙周炎唾液和血清一氧化氮水平的比较：一项生化研究

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Background and Objectives: Nitric oxide (NO) is a ubiquitous intercellular messenger molecule with important cardiovascular, neurological, and immune functions. In addition, it has been postulated that the pharmacological inhibition of NO or its actions may be therapeutically valuable in the disease management. The levels of nitric oxide may provide clues about the severity and the state of the underlying disease process. It could be an inflammatory biomarker that may enable clinicians to direct the environmentally based prevention or treatment programmes and to establish whether NO plays a role in the pathogenesis of periodontitis or not. Hence, the aim of the present study was to evaluate the salivary and the serum levels of NO in generalized chronic and aggressive periodontitis.The Study Design: Unstimulated whole saliva and serum samples were collected from a total of 60 subjects who were in the age group of 18-45 years, who participated in this study. They were divided into three equal groups with 20 subjects in each group; group A (healthy controls), group B (chronic periodontitis) and group C (aggressive periodontitis). The clinical parameters were assessed, based on the oral hygiene index simplified (OHI-S), the gingival index (GI), the probing pocket depth and the clinical attachment loss (CAL). A biochemical analysis was performed to evaluate and compare the salivary and the serum nitric oxide levels of the above groups.Statistical Analysis and Results: The statistical comparisons were done under the Griess Reaction. There were statistically significant salivary and serum levels of NO in the groups of periodontitis (group B and C) as compared to those in the healthy controls (group A). A significant positive correlation was found between the values of the salivary and the serum NO levels in chronic and aggressive periodontitis.Conclusion: Nitric oxide is a potent modulator of the inflammatory disease processes and under pathological conditions, NO has damaging effects. As there is a paucity in the studies which have compared chronic and aggressive periodontitis, this study paved an interest for combining the serum and the salivary analysis in comparing the levels of nitric oxide in chronic and aggressive periodontitis.
机译：背景与目的：一氧化氮（NO）是一种普遍存在的细胞间信使分子，具有重要的心血管，神经和免疫功能。另外，已经假定NO的药理抑制或其作用在疾病管理中可能具有治疗上的价值。一氧化氮的水平可能提供有关潜在疾病过程的严重程度和状态的线索。它可能是一种炎症生物标志物，可以使临床医生指导基于环境的预防或治疗计划，并确定NO是否在牙周炎的发病机理中起作用。因此，本研究的目的是评估广义慢性和侵袭性牙周炎中唾液和血清中一氧化氮的水平。研究设计：从总共60名年龄段的受试者中采集未刺激的全唾液和血清样本参加了这项研究的18-45岁人群。将他们分为三个相等的组，每组20个受试者。 A组（健康对照），B组（慢性牙周炎）和C组（侵袭性牙周炎）。根据简化的口腔卫生指数（OHI-S），牙龈指数（GI），探查袋深度和临床附着丧失（CAL）评估临床参数。进行生化分析以评估和比较上述各组的唾液和血清一氧化氮水平。统计分析和结果：在Griess反应下进行统计比较。与健康对照组（A组）相比，牙周炎组（B和C组）的唾液和血清中NO含量具有统计学意义。在慢性和侵袭性牙周炎中唾液和血清NO含量之间存在显着的正相关。结论：一氧化氮是炎症过程的有效调节剂，在病理条件下，NO具有破坏作用。由于比较慢性和侵袭性牙周炎的研究很少，因此本研究为将血清和唾液分析结合起来以比较慢性和侵袭性牙周炎中的一氧化氮水平感兴趣。

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