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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Myoepithelial Carcinoma of the Breast
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Myoepithelial Carcinoma of the Breast

机译：乳腺癌肌上皮癌

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摘要

Breast carcinoma is the commonest cancer among females in a majority of the Indian cities. The advances in the research and management have improved the breast cancer survival significantly in the past three decades globally. Adenocarcinoma is the commonest histological variant which arises from the ductal epithelia. The myoepithelial cells (ME) are the normal components of the breast parenchyma, which separate the ductal epithelia from the basement membrane and the stroma. The pure ME cell carcinoma is extremely rare and only 38 cases have been reported so far in the indexed literature. This may owe to the difficulties in the identification, and the non availability of established diagnostic criteria. We herein describe the clinical, radiological and the pathological characteristics of a case of myoepithelial carcinoma, to supplement the available literature. The possible impact of these cells in clinical practice was also reviewed. Identification and the further research on the genesis of these tumours, and the pathways by which the ME cells regulate the milieu interior of the breast epithelia, may unravel new molecular targets to prevent or treat both epithelial and myoepithelial cancers at early stages.
机译：在大多数印度城市中，乳腺癌是女性中最常见的癌症。在过去的三十年中，全球研究和管理的进步显着提高了乳腺癌的生存率。腺癌是最常见的组织学变异，起源于导管上皮。肌上皮细胞（ME）是乳房实质的正常组成部分，它们将导管上皮与基底膜和基质分开。单纯的ME细胞癌极为罕见，目前在索引文献中仅报道了38例。这可能归因于识别困难以及无法使用已建立的诊断标准。我们在此描述肌上皮癌病例的临床，放射学和病理学特征，以补充现有文献。还回顾了这些细胞在临床实践中可能产生的影响。对这些肿瘤的发生以及ME细胞调节乳腺上皮细胞内部环境的途径的鉴定和进一步研究，可能会揭示出在早期预防或治疗上皮和肌上皮癌的新分子靶标。

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