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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Nosocomial Infections and Drug Susceptibility Patterns in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus
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Nosocomial Infections and Drug Susceptibility Patterns in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus

机译：敏感和耐甲氧西林金黄色葡萄球菌的医院感染和药敏模式

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Aim: Staphylococcus aureus is one of the leading causes of nosocomial infections and is known for its ability to develop resistance to antibiotics. The drug susceptibility pattern of Methicillin Sensitive S. aureus (MSSA) and Methicillin Resistant S. aureus (MRSA) may vary.Aims and Objectives: This study was carried out to determine and compare the drug susceptibility patterns in nosocomial MSSA and MRSA.Material and Methods: The study was conducted between September 2009 and August 2011. Standard conventional methods were used for the isolation and identification of S. aureus. MRSA was identified by the cefoxitin (30 μg) disk method. Antibiotic susceptibility test was done using Kirby-Bauer disk diffusion method and the interpretation of the results was done using CLSI guidelines.Results: Out of 685 strains of S. aureus studied, 173(25.25%) were MRSA and 512 (74.25%) were MSSA. Out of 173 MRSA strains, 114(65.89%) were isolated from pus, 22(12.71%) from vaginal swab, 18(10.40%) from central catheter tip and the remaining from other specimens. All isolates were susceptible to vancomycin and least number of isolates were susceptible to penicillin. MRSA displayed significantly higher resistance to other antibiotics. 45.7% of MRSA strains were resistant to clindamycin, 64.7% to ciprofloxacin, 87.3% to cotrimoxazole, 54.3% to erythromycin, 17.3% to gentamicin, 16.8% to netilmycin, and 58.38% to tetracycline. Inducible clindamycin resistance was detected in 37 (21.38%) strains of MRSA.Conclusion: Nosocomial infections caused by MRSA is a significant problem. MRSA and MSSA differ with their susceptibility to antibiotics. All MRSA isolates in our hospitals were susceptible to vancomycin. Proper selection of the antibiotics based on antibiotic susceptibility test results is needed for effective treatment and prevention of emergence of resistance in MRSA and MSSA.
机译：目的：金黄色葡萄球菌是医院感染的主要原因之一，以其对抗生素产生耐药性而闻名。目的和目的：本研究旨在确定和比较医院MSSA和MRSA中的药物敏感性模式。本研究旨在确定和比较药物敏感性敏感性的金黄色葡萄球菌（MSSA）和耐甲氧西林金黄色葡萄球菌（MRSA）。方法：该研究在2009年9月至2011年8月之间进行。采用标准的常规方法分离和鉴定金黄色葡萄球菌。通过头孢西丁（30μg）盘法鉴定MRSA。用Kirby-Bauer纸片扩散法进行药敏试验，并用CLSI指南对结果进行解释。结果：在研究的685株金黄色葡萄球菌中，MRSA 173株（25.25％），512株（74.25％） MSSA。在173株MRSA菌株中，从脓液中分离出114株（65.89％），从阴道拭子中分离出22株（12.71％），从中央导管尖端分离出18株（10.40％），其余从其他标本中分离出来。所有分离株均对万古霉素敏感，最少数量的分离株对青霉素敏感。 MRSA对其他抗生素表现出明显更高的抗药性。 MRSA菌株中有45.7％的菌株对克林霉素，环丙沙星，64.7％的环丙沙星，cotrimoxazole的抗药性为87.3％，对红霉素的抗药性为54.3％，对庆大霉素的抗药性为17.3％，对奈替霉素的抗药性为16.8％，对四环素的抗药性为58.38％。在37例（21.38％）MRSA菌株中检测到可诱导的克林霉素耐药性。结论：MRSA引起的医院感染是一个重大问题。 MRSA和MSSA对抗生素的敏感性不同。我们医院的所有MRSA分离株均对万古霉素敏感。为了有效治疗和预防MRSA和MSSA产生耐药性，需要根据抗生素药敏试验结果正确选择抗生素。

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