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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prescribing Pattern of Anti-malarial Drugs with Particular Reference to the use of Artesunate in Complicated Plasmodium Vivax Cases
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Prescribing Pattern of Anti-malarial Drugs with Particular Reference to the use of Artesunate in Complicated Plasmodium Vivax Cases

机译：抗疟药的处方模式，尤其是在复杂的疟原虫病例中使用青蒿琥酯

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Background: In developing countries, Malaria has been found to be one of the most common cause of fever and morbidity, particularly among infants and young children. Therefore, its drug utilization studies should be carried out to know the rationality of treatment. Aim: To evaluate the use of antimalarial agents in children with a diagnosis of Malaria and visited to OPD & IPD Paediatric department of a tertiary care teaching hospital. Materials and Methods: This was a prospective six months study based on a Medication Utilization Form, which has been designed in consultation with the paediatrician. 183 children <12 y of age were selected on the basis of inclusion and exclusion criteria. Results: Out of One hundred eighty three patients, 110 were infected with Plasmodium falciparum (60.10%) and 73 with Plasmodium vivax (39.89%). Most of the patients were male, 56.83% and 43.16% were female patients. Most of the complicated cases were found from Plasmodium falciparum (n = 110) than Plasmodium vivax (n=15). In prescriptions with monotherapy, Artesunate (n=101) was found to be the most commonly prescribed drug and in prescriptions containing more than one drug, Artesunate ? lumefantrine (n=125) combinations were frequently used. Most of the drugs were prescribed by oral route (n=285), than the parenteral route (n=140). The average number of drugs per encounter was 2.32 and only 4.50% drugs were prescribed by generic name. Average drug cost per prescription in complicated cases was found to be higher (185.5 INR) than uncomplicated cases (115 INR). Conclusion: Artemisinin were used as first line drugs irrespective of the causative agent for malaria, which is not recommended, however has been found to be effective in complicated cases of Plasmodium vivax also. The cost of the prescription was higher. Interventions to rectify over prescription of injectables necessary to further improve rational drug use in our facility. Also, there should be an awareness program, especially in slum areas to cut down the transmission of disease.
机译：背景：在发展中国家，疟疾已被发现是发烧和发病的最常见原因之一，尤其是在婴儿和幼儿中。因此，应进行药物利用研究以了解治疗的合理性。目的：评估在诊断为疟疾的儿童中使用抗疟药的情况，并访问了三级教学医院的OPD＆IPD儿科。材料和方法：这是根据药物使用表进行的为期六个月的前瞻性研究，该表是与儿科医生协商设计的。根据纳入和排除标准选择了183个<12岁的儿童。结果：在183例患者中，有110例感染了恶性疟原虫（占60.10％），73例感染了间日疟原虫（占39.89％）。多数患者为男性，女性为56.83％，女性为43.16％。大多数复杂病例是从恶性疟原虫（n = 110）而不是间日疟原虫（n = 15）发现的。在采用单一疗法的处方中，青蒿琥酯（n = 101）被发现是最常用的处方药，在含有一种以上药物的处方中，青蒿琥酯是？经常使用lumantantrine（n = 125）组合。与非肠道途径（n = 140）相比，大多数药物是通过口服途径（n = 285）开处方的。每次遭遇的平均药物数量为2.32，而通用名称仅规定了4.50％的药物。发现在复杂情况下，每张处方的平均药品费用（185.5 INR）比未复杂情况下更高（115 INR）。结论：青蒿素被用作一线药物，与疟疾的致病因素无关，不建议使用，但已发现在复杂的间日疟原虫病例中也有效。处方的费用较高。为进一步改善我们工厂合理用药所必需的干预措施，以纠正注射剂的超标情况。另外，应该有一个提高意识的计划，特别是在贫民窟地区，以减少疾病的传播。

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