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首页> 外文期刊>Journal of Clinical and Diagnostic Research >?Comparative Efficacy of Different Doses of Fentanyl on Cardiovascular Responses to Laryngoscopy and Tracheal Intubation?
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?Comparative Efficacy of Different Doses of Fentanyl on Cardiovascular Responses to Laryngoscopy and Tracheal Intubation?

机译：不同剂量的芬太尼对喉镜和气管插管的心血管反应的比较功效

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Background: This study was conducted to determine an effective bolus dose of fentanyl, which would attenuate the cardiovascular response to laryngoscopy and tracheal intubation. Materials and Methods: A randomised double blind controlled study was carried out on 50 healthy adult patients (ASA I and II) undergoing elective surgery under general anaesthesia. The patients were randomly allocated into two groups of 25 each i.e. group A and group B receiving fentanyl 3 ?g/kg, 5 ?g/kg intravenously three minutes before intubation respectively. The pulse rate, systolic blood pressure was recorded at induction, during intubation and at 1,3, 5 min post intubation. Results:The study showed that both the doses were equally effective in blunting the pulse rate response, but the 5?g /kg proved significantly effective in blunting the blood pressure response. The rate pressure product, a measure of cardiac O2 consumption was found to be significantly lower in fentanyl 5?g/kg compared to fentanyl 3?g/kg. Conclusion: So, we conclude that both blood pressure and rate pressure product were completely abolished by a bolus dose of fentanyl 5?g /kg in comparison with fentanyl 3?g/kg following laryngoscopy and intubation.
机译：背景：进行这项研究来确定芬太尼的有效推注剂量，该剂量会减弱对喉镜和气管插管的心血管反应。材料与方法：对50名在全身麻醉下接受择期手术的健康成人患者（ASA I和II）进行了一项随机双盲对照研究。将患者随机分为两组，每组25个，即A组和B组分别在插管前3分钟静脉注射芬太尼3μg/ kg，5μg/ kg。在诱导过程中，插管过程中以及插管后1、3、5分钟记录脉搏率，收缩压。结果：研究表明，两种剂量均能有效地减弱脉搏率反应，但5μg/ kg的剂量可有效抑制血压反应。相比于芬太尼3微克/千克，芬太尼5微克/千克的速率压力乘积（一种测量心脏O2的消耗量）明显降低。结论：因此，我们得出的结论是，与喉镜和插管后的芬太尼3μg/ kg相比，芬太尼5μg/ kg的推注剂量完全消除了血压和速率压力乘积。

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