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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Hyaluronic Acid in Early Diagnosis of Knee Osteoarthritis
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Role of Hyaluronic Acid in Early Diagnosis of Knee Osteoarthritis

机译：透明质酸在膝骨关节炎早期诊断中的作用

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Introduction: Osteoarthritis of knee is traditionally diagnosed on the basis of clinical and radiological findings. Usually joint tissue degeneration is already advanced by the time a clinical diagnosis is made, hence the research focus has now shifted to use of biomarkers to diagnose the condition at an early stage of the disease. Aims & Objectives: The aim of this study was to assess the efficacy of serum HA levels in early detection and grading of the severity of primary knee osteoarthritis and it?s co-relation with Western Ontario and McMaster university osteoarthritis index (WOMAC scores) and Kellgren -Lawrence grading (K-L grade). Materials and Methods: The study included 150 subjects (100 cases and 50 controls) and all were subjected to WOMAC scoring and K-L grading and estimation of serum HA levels. Results: Age and WOMAC scores have significant correlation with HA levels, but multivariate analysis shows only WOMAC score as an independent variable associated with HA levels. The results show statistically significant high HA levels in cases than in normal population. HA levels are also able to differentiate between various clinical severity grades. ROC Curve analysis suggests cut-off levels of HA between mild, moderate and severe cases. Conclusion: HA levels are able to differentiate between normal asymptomatic population and symptomatic cases and also between various severity grades of osteoarthritis
机译：简介：膝骨关节炎传统上是根据临床和影像学检查结果诊断的。通常，在进行临床诊断时，关节组织变性已经提前，因此研究重点已转移到使用生物标记物来诊断疾病的早期阶段。目的与目的：本研究旨在评估血清HA水平在早期发现和分级原发性膝骨关节炎严重程度中的功效，以及与西安大略省和麦克马斯特大学骨关节炎指数（WOMAC评分）和凯格伦-劳伦斯分级（KL等级）。材料和方法：该研究包括150名受试者（100例和50名对照），所有受试者均接受WOMAC评分和K-L评分，并评估血清HA水平。结果：年龄和WOMAC评分与HA水平显着相关，但是多变量分析显示，只有WOMAC评分是与HA水平相关的自变量。结果表明，与正常人群相比，病例中的高HA水平具有统计学意义。 HA水平还能够区分各种临床严重程度等级。 ROC曲线分析表明轻度，中度和重度病例之间的HA截止水平。结论：HA水平能够区分正常无症状人群和有症状病例，以及不同严重程度的骨关节炎

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