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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Serodiagnosis of Scrub Typhusat a Tertiary Care Hospitalfrom Southern India
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Serodiagnosis of Scrub Typhusat a Tertiary Care Hospitalfrom Southern India

机译：印度南部三级保健医院的斑疹伤寒的血清学诊断

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Introduction: Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections. There is an upsurge in the incidence of the disease worldwide with ever-changing habitat. Clinical diagnosis of scrub typhus is challenging as the signs and symptoms of scrub typhus are similar to other febrile illnesses. In developing countries, among the various laboratory tests to diagnose scrub typhus, WeilFelix test is commonly performed despite its low sensitivity. The Immunofluorescence antibody (IFA) test has its limitations in terms of cost and expertise required. The present study was conducted to determine the seropositivity of IgM ELISA for scrub typhus in clinically suspected cases. Materials and Methods: Weil-Felix test and IgM ELISA were performed using clinically suspected cases of scrub typhus using commercially available kits. Results: Out of 482 samples tested, 109 were positive by both Weil-Felix test and IgM ELISA. One hundred and sixteen samples which were negative by Weil-Felix test reacted positive by IgM ELISA. Fourteen samples which were positive by WeilFelix test were negative by ELISA. Conclusion: Owing to the limitations of the Weil-Felix test and IFA, commercially available recombinant IgM ELISA which has a good sensitivity and specificity may be an alternative in laboratories with moderate set up.
机译：简介：斑疹伤寒是一种人畜共患病，是最隐蔽的新兴和再出现的立克次氏菌感染之一。随着生境的不断变化，全世界该病的发病率正在上升。斑疹伤寒的临床诊断具有挑战性，因为斑疹伤寒的体征和症状与其他高热疾病相似。在发展中国家，在各种诊断灌木斑疹伤寒的实验室测试中，WeilFelix测试尽管灵敏度低，但仍经常进行。免疫荧光抗体（IFA）测试在成本和所需专业知识方面有其局限性。本研究旨在确定临床疑似病例中IgM ELISA对斑疹伤寒的血清阳性。材料和方法：使用临床上可疑的灌木斑疹伤寒病例，使用市售试剂盒进行Weil-Felix试验和IgM ELISA。结果：在测试的482个样本中，Weil-Felix测试和IgM ELISA均为109个阳性。 Weil-Felix试验阴性的116个样品通过IgM ELISA反应阳性。通过WeilFelix测试阳性的14个样品通过ELISA阴性。结论：由于Weil-Felix试验和IFA的局限性，具有良好的敏感性和特异性的市售重组IgM ELISA可能是中等规模实验室中的替代方法。

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