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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The efficacy of the epidural depo-methylprednisolone and triamcinolone acetate in relieving the symptoms of lumbar canal stenosis: A comparative study
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The efficacy of the epidural depo-methylprednisolone and triamcinolone acetate in relieving the symptoms of lumbar canal stenosis: A comparative study

机译：硬膜外去甲基强的松龙和醋酸曲安奈德缓解腰椎管狭窄症的疗效比较研究

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Objective: To compare the efficacy of depo-methylprednisolone and triamcinolone acetate in pain relief and in the improvement in claudication distance after two doses of epidural injections in patients with clinically diagnosed lumbar canal stenosis.Material and Methods: This prospective, randomized trial was performed in seventy patients with the clinical features of lumbar canal stenosis, who received epidural medications for pain relief. The patients were grouped into two; the T group receiving an injection of 80mg triamcinolone acetate with bupivacaine (0.125%) diluted in normal saline and the M group receiving 80 mg methylprednisolone acetate with bupivacaine (0.125%) diluted in normal saline solution (total volume of 20 ml in each group). The pain relief was assessed at 1, 3 and 6 months post-procedurally for improvement in the VAS pain scores and for the increase in the claudication distance. Results: Of the 70 patients who were included in the study, 40% were females (n=28) and 60% were males (n=42). In the M group, 24 patients (68.5%) reported improvement in the VAS pain scores at the end of 6 months, as compared to 14 (40%) patients in the T group. The pre-intervention mean claudication distance was 163 meters in the group M and 170 meters in the group T, which improved to 637 metres and 350 meters in groups M (P 0.05) respectively, at the end of a 6 month follow up. In group M, the average VAS scores decreased from 7.34 in the pre-treatment phase, to 3.64 at the end of a 6 month follow up, which was significantly low (P=0.02). Comparatively, in group T the pre-treatment VAS score value decreased from 6.4 to 4.8 after 6 months of treatment (P< 0.05). Conclusion: Both triamcinolone and methylprednisolone are effective epidural medications for symptomatic relief in lumbar canal stenosis, though depo-methylprednisolone showed better long term pain relief and improved walking distance at long term intervals as compared to triamcinolone.
机译：目的：比较在临床确诊的腰椎管狭窄症患者中，去甲甲基强的松龙和醋酸曲安奈德在两次疼痛硬膜外注射后的疼痛缓解和lau行距离改善的疗效。材料与方法：该前瞻性随机试验于2007年进行。患有腰椎管狭窄的临床特征的70例患者，接受了硬膜外药物缓解疼痛。将患者分为两部分。 T组接受在生理盐水中稀释的80mg醋酸曲安西龙与布比卡因（0.125％）的注射液，M组接受在生理盐水中稀释的80 mg醋酸甲泼尼龙（0.125％）于生理盐溶液中稀释（总体积为20 ml在每个组中）。在手术后1、3和6个月评估疼痛缓解情况，以改善VAS疼痛评分并增加c行距离。结果：纳入研究的70名患者中，女性占40％（n = 28），男性占60％（n = 42）。在M组中，有24名患者（68.5％）在6个月结束时报告了VAS疼痛评分的改善，相比之下，T组中有14名患者（40％）。干预前的平均lau行距离在M组为163米，在T组为170米，在随访6个月结束时，M组分别为637米和350米（P 0.05）。在M组中，平均VAS评分从治疗前的7.34下降到随访6个月末的3.64，这是非常低的（P = 0.02）。相比之下，在T组中，治疗6个月后，治疗前VAS评分值从6.4降低至4.8（P <0.05）。结论：曲安西龙和甲基强的松龙都是有效的硬膜外药物，可缓解腰椎管狭窄症，尽管与曲安西龙相比，去甲甲基强的松龙在长期间隔内显示出更好的长期疼痛缓解和改善的步行距离。

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