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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of CSF CK, LDH, GGTP Enzyme Levels in Diagnostic and Prognostic Evaluation of Meningitis
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Role of CSF CK, LDH, GGTP Enzyme Levels in Diagnostic and Prognostic Evaluation of Meningitis

机译：脑脊液CK，LDH，GGTP酶水平在脑膜炎诊断和预后评估中的作用

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Background: Aetiological diagnosis for meningitis remains a challenge and often a thorough Cerebrospinal fluid (CSF) examination may not give a precise diagnosis as at times CSF findings may simulate meningitis like picture as in carcinomatous meningitis, chemical meningitis, early stages of Guillan bare syndrome, subarachnoid hemorrhage, ICSOL, brain abscess, intracranial extension of epidural or subdural infection. Lesions of tissue rich in enzymes may cause enzymatic release on tissue destruction, so also in meningitis and many enzymes are known to be present in abundance in nervous system.Aim: To evaluate the diagnostic and prognostic significance of Creatine Kinase (CK), Lactate Dehydrogenase (LDH) and Gamma Glutamyl Transpeptidase (GGTP) enzymes in CSF of meningitis. Materials and Methods: A prospective cases control study of pyogenic and tubercular meningitis patients of 44 cases admitted in department of medicine from September 2011-September 2012 was done. Enzymes like CK, LDH and GGTP were estimated on day 0 (day of admission) and 7th day in the CSF and in serum. CSF and serum CK, LDH, GGTP was estimated on 0th day 0 only in cases of controls.Result: Out of 44 patients, total 32 were tubercular meningitis and 12 were pyogenic meningitis. Mean CSF CK, LDH levels were significantly raised in both conditions with respect to controls in day 0 with p < 0.0001 and p < 0.05 respectively. Mean CSF CK, LDH level were also significantly reduced from 0 to 7th day in both tubercular, pyogenic meningitis, while CSF GGTP was not significantly raised with respect to control in day 0.Conclusion: Enzymes level in CSF like CK, LDH are significantly raised in the meningitis and accessing its value can be an important diagnostic and prognostic marker. But more studies are required to establish the usefulness of estimating these enzymes.
机译：背景：脑膜炎的病因学诊断仍然是一个挑战，经常进行彻底的脑脊液（CSF）检查可能无法提供准确的诊断，因为有时CSF的发现可能会模拟脑膜炎，如癌性脑膜炎，化学性脑膜炎，早期Guillan裸综合征，蛛网膜下腔出血，ICSOL，脑脓肿，颅内硬膜外或硬膜下感染扩大。富含酶的组织病变可能在组织破坏时引起酶释放，因此在脑膜炎中也是如此，并且已知许多酶会大量存在于神经系统中。目的：评估肌酸激酶（CK），乳酸脱氢酶的诊断和预后意义（LDH）和Gamma谷氨酰转肽酶（GGTP）酶在脑膜炎的脑脊液中。材料与方法：对2011年9月至2012年9月收治的44例化脓性和结核性脑膜炎患者进行前瞻性病例对照研究。在CSF和血清中的第0天（入院日）和第7天估计了CK，LDH和GGTP等酶。仅在对照组第0天0天才估计CSF和血清CK，LDH，GGTP。结果：44例患者中，结核性脑膜炎共32例，化脓性脑膜炎12例。在第0天，相对于对照，两种情况下的平均CSF CK，LDH水平均显着升高，分别为p <0.0001和p <0.05。结核性化脓性脑膜炎的平均CSF CK，LDH水平也从0天降低至第7天，而相对于对照组，CSF GGTP在第0天并未显着升高。结论：CSF中的酶水平（如CK，LDH）显着升高在脑膜炎中，获得其价值可能是重要的诊断和预后指标。但是需要更多的研究来确定估计这些酶的有效性。

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