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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Diclofenac-Serratiopeptidase Combination Induced Stevens ? Johnson Syndrome - A Rare Case Report with Review of Literature
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Diclofenac-Serratiopeptidase Combination Induced Stevens ? Johnson Syndrome - A Rare Case Report with Review of Literature

机译：双氯芬酸-锯齿肽肽酶组合诱导史蒂文斯？约翰逊综合症-罕见病例报告并文献复习

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摘要

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions (SCAR) which are frequently caused by exposure to drugs and cause significant morbidity and mortality. A careful literature search revealed that only a few reports of diclofenac induced and one case of serratiopeptidase associated case report of SJS or TEN have been published till date. However, to our knowledge, no case report of diclofenac-serratiopeptidase combination induced SJS have been published till date. In this backdrop, we describe the first case of a 62-year-old woman who developed diffuse, erythematous rash on face, trunk and both extremities which later turned into blisters following five day treatment with diclofenac and serratiopeptidase combination. There was extensive ulceration of buccal, genital and ocular mucosa. The body surface area involvement of the patient at the time of presentation was 9%. A provisional diagnosis of SJS was made by the treating physician. After administration of intravenous antibiotic, topical antiseptic, anti-histamine, topical lubricants, fluid therapy and parenteral nutrition patient recovered and were discharged.
机译：史蒂文斯－约翰逊综合症（SJS）和中毒性表皮坏死溶解（TEN）是严重的皮肤不良反应（SCAR），通常由接触药物引起，并导致明显的发病率和死亡率。仔细的文献检索显示，迄今为止，仅发表了几份双氯芬酸诱导的报道和1例与SJS或TEN的血清素肽酶相关的病例报道。然而，据我们所知，迄今为止，尚未发表双氯芬酸-锯齿肽酶联合诱导的SJS的病例报告。在此背景下，我们描述了第一例62岁的女性，该女性在面部，躯干和两个肢体上均出现了弥漫性红斑皮疹，随后在用双氯芬酸和serratiopeptidase联合治疗5天后变成了水泡。颊，生殖器和眼粘膜广泛溃疡。就诊时患者的体表受累率为9％。主治医师对SJS进行了临时诊断。静脉注射抗生素后，外用防腐剂，抗组胺药，外用润滑剂，液体疗法和肠胃外营养患者recovered愈出院。

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