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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?
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A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

机译：一项双盲，RCT测试有利于中年生活方式增强型受试者中BDNF的有益调节：脑保护的线索吗？

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Introduction: The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown to protect experimental stress-induced hyppocampal degeneration, could beneficially modulate BDNF, as measured in the serum, in otherwise healthy but work-stressed individuals.Methodology: Forty-eight men and women between the ages of 38 and 62 reporting high-demanding work activity but with an overall positive attitude towards their personal life were recruited. Subjects were divided in two group (24 patients each) and blindly supplemented for 2 month with: a) LD-1227 400mg or b) placebo. A third group of healthy non-stressed subjects was used as well. Blood samples were taken before and after the supplementation period. Unstimulated saliva was collected and tested for amylase while serum levels were used to measure BDNF. State Trait Anxiety Inventory (STAI), Pittsburgh Sleep Quality Index (PSQI) and psychological well-being assessment (PSWB) were measured too. Patients with Val66Met functional polymorphism of BDNF excluded those given their reported association with an impaired release of BDNF.Results: Results showed that, as compared to healthy, non-stressed individuals, stressed ones has a trend decrease of BDNF and this was significantly increased by LD 12-1227 supplementation and the same inverse phenomenon occurred to salivary amylase (p<0.05). No change was noted in the PSQI score but, either STAI or PSWB tests scored better in LD-1227 supplemented subjects.Conclusion: the present data suggest that LD-1227 is beneficially affecting neuromodulation and related symptoms during common stressful life conditions and may have the potential as tools in a neuroprotective clinical strategy.
机译：简介：这项前瞻性研究的目的是观察LD-1227（一种能控制实验压力引起的海马体变性的质量受控的海洋营养品）是否可以有益地调节血清中的BDNF，而在健康但工作压力较大的情况下方法：招募了38位年龄在38至62岁之间的男性和女性，他们报告了高要求的工作活动，但对他们的个人生活总体上持积极态度。将受试者分为两组（每组24位患者），并盲目补充2个月：a）LD-1227 400mg或b）安慰剂。还使用了第三组健康的无压力受试者。在补充期之前和之后采集血样。收集未刺激的唾液并测试淀粉酶，同时使用血清水平测量BDNF。还测量了国家特质焦虑量表（STAI），匹兹堡睡眠质量指数（PSQI）和心理健康评估（PSWB）。 Val66Met BDNF功能多态性的患者被排除，因为据报道其与BDNF释放受损有关。结果：结果显示，与健康，无压力的人相比，压力人的BDNF有下降的趋势，并且显着增加。 LD 12-1227的补充和唾液淀粉酶发生了相同的逆现象（p <0.05）。 PSQI评分未见变化，但在补充LD-1227的受试者中，STAI或PSWB测试得分均较高。结论：目前的数据表明LD-1227在普通压力生活条件下有益地影响神经调节和相关症状，并且可能具有作为神经保护性临床策略工具的潜力。

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