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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients
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Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients

机译：扁平苔藓患者唾液皮质醇与焦虑水平的关系

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Background: Oral lichen planus (OLP) is a frequently encountered chronic inflammatory disease of oral mucosa and skin, where the patients often relate the onset and aggravation of oral symptoms to increased levels of stress. Cortisol, also called as ?stress hormone? has been used as an indicator in various stress evaluation studies. Aim: The aim of this cross-sectional study was to determine any association between anxiety and salivary cortisol levels in OLP patients. Materials and Methods: A total of 20 OLP patients along with same number of age and sex matched healthy controls were included in the study. Saliva was collected from all the subjects between 9.00 to 9.15 am to avoid diurnal variations of cortisol levels. The saliva samples were analysed for cortisol levels by competitive enzyme-linked immunosorbent assay (ELISA) method. Anxiety levels of 40 patients were measured by using Hamilton?s anxiety scale. Student?s t-test was used to compare the anxiety and salivary cortisol levels between both groups. Results: The mean salivary cortisol level of the OLP group showed highly significant difference (p<0.001) from the controls. The mean anxiety scores of the OLP group showed highly significant difference (p<0.001) from the controls. A positive correlation was found between anxiety and salivary cortisol levels in the OLP patients. Conclusion: These findings suggest that anxiety play a vital role in the pathogenesis of OLP, thus besides traditional treatment, psychological support is also needed.
机译：背景：扁平苔藓（OLP）是口腔粘膜和皮肤的一种常见的慢性炎症性疾病，患者通常将口腔症状的发作和加重与压力增加有关。皮质醇，也称为“应激激素”。在各种压力评估研究中已被用作指标。目的：这项横断面研究的目的是确定OLP患者焦虑与唾液皮质醇水平之间的任何关联。材料和方法：总共20名OLP患者以及相同数量的年龄和性别匹配的健康对照者被纳入研究。在上午9:00至9.15之间收集所有受试者的唾液，以避免皮质醇水平的昼夜变化。通过竞争性酶联免疫吸附测定（ELISA）方法分析唾液样品中的皮质醇水平。使用汉密尔顿焦虑量表测量40名患者的焦虑水平。学生的t检验用于比较两组之间的焦虑和唾液皮质醇水平。结果：OLP组的唾液皮质醇平均水平与对照组相比有极显着差异（p <0.001）。 OLP组的平均焦虑评分与对照组相比有极显着差异（p <0.001）。发现OLP患者的焦虑与唾液皮质醇水平呈正相关。结论：这些发现表明焦虑症在OLP的发病机理中起着至关重要的作用，因此除传统治疗外，还需要心理支持。

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