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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prognostic Significance of Lymph Node Pattern in Oral Squamous Cell Carcinoma (OSCC)
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Prognostic Significance of Lymph Node Pattern in Oral Squamous Cell Carcinoma (OSCC)

机译：口腔鳞状细胞癌（OSCC）淋巴结模式的预后意义

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Background: Assessment of lymph node reactivity pattern is an important indicator of the host response status and prognosis of oral squamous cell carcinoma (OSCC).Aim: To assess the prognostic significance of lymph node reactivity patterns in OSCC.Settings and Design: This is a cross-sectional study aimed correlating host status and prognosis of OSCC.Materials and Method: Morphological patterns of lymph nodes received from 30 histologically proven cases of OSCC were analyzed. Five different patterns of the lymph node reaction were categorized (lymphocytic predominance, germinal center predominance, sinus histiocytosis, normal lymph node and lymphocytic depleted) and compared with the prognosis of OSCC.Statistical Analysis Used: TNM, Histological grading parameters and Lymph node reactivity pattern were compared with the event of recurrence of OSCC and death of patient using Fisher?s Exact test. Survival of the patients was analyzed for association with lymph node patterns using Log rank test. Results: Recurrence of the tumour was seen in association with all the patterns, with higher rates of mortality seen in patients with sinus histiocytosis of lymph node.Conclusion: Morphological pattern being an aid in predicting prognosis, cannot be used as a lone predictor. An attempt is made to identify and discuss the possible pathogenesis for the reaction patterns.
机译：背景：淋巴结反应模式的评估是口腔鳞状细胞癌（OSCC）宿主反应状态和预后的重要指标。目的：评估淋巴结反应模式在OSCC中的预后意义。材料和方法：分析了30例经组织学证实的OSCC淋巴结的形态学模式。将淋巴结反应的五种不同类型（淋巴细胞优势，生发中心优势，窦组织细胞增多，正常淋巴结和淋巴细胞减少）与OSCC的预后进行比较。统计分析：TNM，组织学分级参数和淋巴结反应性模式用Fisher精确检验将OSCC复发和患者死亡进行比较。使用对数秩检验分析患者的存活与淋巴结模式的相关性。结果：肿瘤的复发与所有类型相关，在窦房结淋巴结组织增生症患者中死亡率更高。结论：形态学模式有助于预测预后，不能作为单独的预测因子。试图识别和讨论反应模式的可能发病机理。

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