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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients
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A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients

机译：评估氧化性低密度脂蛋白，小密度低密度脂蛋白，脂蛋白（a）和载脂蛋白的血脂分布在甲状腺功能减退患者心血管风险评估中的研究

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Introduction: Hypothyroidism is one of the most common metabolic disorders associated with dyslipidemia which poses a higher risk of Coronary Artery Disease (CAD) in such patients. Biochemical markers which can pick up the risk promptly are becoming imperative now-a-days and thus the assessment beyond the conventional lipid profile is the need of the hour.Aims: To assess the association of non-conventional lipid parameters like small dense Low Density Lipoprotein (sd LDL), oxidized Low Density Lipoprotein (ox LDL), Apolipoprotein A (Apo A1), Apolipoprotein B (Apo B) and Lipoprotein (a) {Lp(a)} in hypothyroid patients and compare their values with the conventional lipid parameters such as Total Cholesterol (TC), Triglyceride (TG), Low-Density Lipoprotein Cholesterol (LDL-C) and High-Density Lipoprotein Cholesterol (HDL-C). Materials and Methods: One hundred and thirty clinically proven patients of hypothyroidism aged 20-60 years and equal number of age and gender matched healthy individuals were included in this case control study. Serum sd LDL, ox LDL, Apo A1, Apo B, Lp (a), lipid profile, Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3 ) and Free Tetraiodothyronine (FT4 ) levels were measured in both the groups. The data was recorded and analysed on SPSS system. The results of cases and controls were compared by student t-test and one-way ANOVA. All the parameters were correlated with TSH by Pearson?s correlation. Results: We found significantly high levels of sd LDL, ox LDL, Apo B, Lp (a), TC, TG, LDL-C in cases as compared to the controls. Ox LDL has shown maximum correlation with serum TSH (p<0.0001, r=0.801) followed by sd LDL (p<0.0001, r=0.792), Apo B (p<0.001, r=0.783) and LDL-C (p<0.001, r=0.741). Moreover, ox LDL and sd LDL were found to be increased in normolipidemic hypothyroid patients thereby giving a strong supportive evidence that estimation of these parameters can become fundamental in prompt identification of the high risk patients of CAD in hypothyroid population.Conclusion: Non-conventional lipid parameters appear to be better markers for the assessment of cardiovascular risk in hypothyroidism and might help in the designing of the effective treatment protocols and areas of intervention by the clinicians as well as researchers.
机译：简介：甲状腺功能减退症是与血脂异常有关的最常见的代谢性疾病之一，在这类患者中冠状动脉疾病（CAD）的风险更高。如今，如今，当务之急是能够迅速承担风险的生化标记物，因此需要超越常规脂质谱进行评估。目的：评估非常规脂质参数（如小而稠密的低密度）的关联甲状腺功能低下患者的脂蛋白（sd LDL），氧化型低密度脂蛋白（ox LDL），载脂蛋白A（Apo A1），载脂蛋白B（Apo B）和脂蛋白（a）{Lp（a）}，并将其值与常规脂质比较参数，如总胆固醇（TC），甘油三酸酯（TG），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。材料与方法：这项病例对照研究包括了120名20-60岁的临床证实的甲状腺功能减退患者以及年龄和性别相同的健康个体。两组均测量血清sd LDL，ox LDL，Apo A1，Apo B，Lp（a），脂质分布，甲状腺刺激激素（TSH），游离三碘甲状腺素（FT3）和游离四碘甲状腺素（FT4）水平。在SPSS系统上记录并分析数据。通过学生t检验和单向方差分析比较病例和对照的结果。通过皮尔逊相关将所有参数与TSH相关。结果：与对照组相比，我们发现病例中的sd LDL，ox LDL，Apo B，Lp（a），TC，TG，LDL-C显着升高。 Ox LDL与血清TSH（p <0.0001，r = 0.801），sd LDL（p <0.0001，r = 0.792），Apo B（p <0.001，r = 0.783）和LDL-C（p < 0.001，r = 0.741）。此外，在正常血脂不足的甲状腺功能减退患者中发现ox LDL和sd LDL升高，从而提供了有力的支持证据，这些参数的估计对于迅速识别甲状腺功能低下的CAD高危患者至关重要。这些参数似乎是评估甲状腺功能减退症中心血管疾病风险的更好标志，并且可能有助于设计有效的治疗方案和临床医生以及研究人员的干预领域。

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