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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Burkholderia Infections in Diabetic Patients Emerging as a Challenge for Physicians: A Case Series
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Burkholderia Infections in Diabetic Patients Emerging as a Challenge for Physicians: A Case Series

机译：糖尿病患者中出现的伯克霍尔德菌感染对医生构成挑战：一个病例系列

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The genus Burkholderia comprises more than 40 species. Medically important members of this genus are Burkholderia cepacia (B.cepacia), Burkholderia pseudomallei (B.pseudomallei) and Burkholderia mallei (B.mallei). Burkholderia cepacia complex (Bcc) can cause Cepacia syndrome which includes necrotising pneumonia, respiratory failure and bacteremia in Cystic Fibrosis (CF) patients and can be fatal. B.cepacia can be potentially pathogenic in individuals with impaired host defences and can cause pneumonia, bronchiectasis, pyopneumothorax and cavitatory lesions. The clinical manifestations of Melioidosis range from localised infection to overwhelming sepsis and death with Pneumonia being the most common presentation. The most significant risk factor for Melioidosis is diabetes. Musculoskeletal Melioidosis is not common in India even though sporadic cases have been reported mostly involving soft tissues. In the present two cases of Melioidosis in diabetics who presented with septic arthritis treated with surgical debridement followed by antibiotics and two cases of Cepacia syndrome in diabetics whose hospital course was complicated by pneumothorax and Acute Respiratory Distress Syndrome (ARDS). These reports raise the concern regarding the potential severity of Burkholderia infections and prompts early diagnosis by physicians to prevent morbidity and mortality.
机译：伯克霍尔德氏菌属包括40多种。该属的医学上重要的成员是洋葱伯克霍尔德氏菌（B.cepacia），假伯克霍尔德氏菌（B.pseudomallei）和马齿伯克霍尔德氏菌（B.mallei）。 Burkholderia cepacia complex（Bcc）会引起Cepacia综合征，包括囊性纤维化（CF）患者的坏死性肺炎，呼吸衰竭和菌血症，并且可能是致命的。头孢杆菌病在宿主防御能力受损的个体中可能具有潜在的致病性，并可能引起肺炎，支气管扩张，脓胸和气蚀性病变。鼻疽病的临床表现包括局部感染，败血症和死亡，其中以肺炎最为常见。发生类痔病的最重要风险因素是糖尿病。尽管据报道散发性病例主要涉及软组织，但肌肉骨骼类痔疮在印度并不常见。在本例中，有2例在糖尿病患者中发生了类鼻疽病，其中有化脓性关节炎并接受了外科清创术治疗，随后应用了抗生素;还有2例在糖尿病患者中合并了气胸和急性呼吸窘迫综合征（ARDS）的糖尿病患者出现了Cepacia综合征。这些报告引起人们对伯克霍尔德氏菌感染的潜在严重性的关注，并促使医生及早诊断以预防发病率和死亡率。

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