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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Bone Mineral Density among Lean Type II Diabetes Mellitus Patients-A Cross-sectional Comparative Study
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Bone Mineral Density among Lean Type II Diabetes Mellitus Patients-A Cross-sectional Comparative Study

机译：瘦型II型糖尿病患者的骨矿物质密度-横断面比较研究

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In case of diabetes mellitus, the pathological process behind fragility of the bone are complex. This process is found to be mediated by various factors like hyperglycaemia, oxidative stress and the accumulation of products of glycation.Aim: To study bone mineral density in lean diabetics and to compare with normal population.Materials and Methods: The present study was undertaken as a cross-sectional comparative study among 60 participants (30 cases of lean diabetics and 30 normal controls). The convenient sampling technique was done to select study participants and the study was carried out during the period from January 2015 to December 2016. Patients who were already a known case of Type 2 diabetes mellitus or newly diagnosed to have Type 2 diabetes mellitus whose BMI was <18.5 kg/m2 were considered as cases. Chi-square test was used for finding a statistically significant difference in proportions; Independent student t-test was used for finding the statistically significant difference between means; Pearson?s correlation coefficient was estimated for finding linear association between two continuous variables; a p-value <0.05 was considered to be statistically significant.Results: On comparison of cases with controls no statistically significant differences were observed between the two groups in terms of age, waist-hip ratio and BMI (p-value >0.05). Bone mineral density parameters were found to be significantly lower among lean diabetes mellitus patients. HbA1C was found to negatively correlate with that of bone mineral density.Conclusion: Osteopenia and osteoporosis, characterised by low bone mineral density values were found to be highly prevalent among lean diabetics.
机译：在糖尿病的情况下，骨骼脆弱性的病理过程是复杂的。已发现此过程是由多种因素介导的，例如高血糖症，氧化应激和糖基化产物的积累。目的：研究瘦型糖尿病患者的骨矿物质密度并与正常人群进行比较。材料和方法：本研究是在60名参与者（30例瘦型糖尿病患者和30例正常对照）之间进行的横断面比较研究。在2015年1月至2016年12月期间进行了方便的抽样技术以选择研究参与者。该患者已经是已知的2型糖尿病病例或新诊断出的BMI为2的2型糖尿病患者。 <18.5 kg / m2被视为案例。卡方检验用于发现比例的统计学差异;独立学生t检验用于发现均值之间的统计学显着性差异;估计皮尔森的相关系数，以发现两个连续变量之间的线性关系。 p值<0.05被认为具有统计学意义。结果：在与对照组进行比较的情况下，两组之间在年龄，腰臀比和BMI方面均未观察到统计学上的显着差异（p值> 0.05）。发现瘦型糖尿病患者的骨矿物质密度参数明显较低。发现HbA1C与骨矿物质密度呈负相关。结论：骨质疏松和骨质疏松症以低的骨矿物质密度值为特征，在瘦型糖尿病患者中非常普遍。

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