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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Coronary Artery Disease risk factors in Type 2Diabetes mellitus with metabolic syndrome inthe urban South Indian population
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Coronary Artery Disease risk factors in Type 2Diabetes mellitus with metabolic syndrome inthe urban South Indian population

机译：南印度城市人群代谢综合征的2型糖尿病的冠状动脉疾病危险因素

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Introduction:Insulin resistance increases the risk of developing metabolic syndrome, a major cause of dyslipidaemia and heart disease. Metabolic syndrome is a cluster of metabolic risk factors that come together in a single individual. Hence, in the present study, the occurrence of metabolic syndrome among type 2 diabetes mellitus patients by the WHO criteria has been carried out. The risk factors were compared between patients with type 2 diabetes mellitus, with and without metabolic syndrome. Materials and Methods:Eighty seven, age matched, type 2 diabetic patients who attended a diabetic clinic were included in this study. They were grouped as diabetic patients with metabolic syndrome and diabetic patients without metabolic syndrome, based on the WHO criteria. The biochemical parameters like fasting blood sugar (FBS), post prandial blood sugar (PPBS) and lipid profile were estimated by using diagnostic kits. The bloodpressure (BP) was measured and the body mass index (BMI) and the atherogenic index of plasma (AIP) were calculated. Statistical analysis was done by the Student?s t test. Results:The occurrence of metabolic syndrome among the type 2 diabetic patients was 33%. A significant increase was seen in triglycerides (TGLs), very low density lipoproteins (VLDLs), the TGL/HDL ratio, AIP, BP and BMI and a decrease was observed in the high density lipoproteins (HDLs) of type 2 diabetic patients with metabolic syndrome when compared with the type 2 diabetic patients without metabolic syndrome. Conclusion:The significant increase in the TGLs, the TGL/HDL ratio, AIP, BP and the BMI of diabetic patients with metabolic syndrome when compared to the type 2 diabetic patients without metabolic syndrome, predicts that patients with type 2 diabetes mellitus with metabolic syndrome are at a higher risk level for coronary heart disease (CHD).
机译：简介：胰岛素抵抗会增加发生代谢综合征的风险，而代谢综合征是血脂异常和心脏病的主要原因。代谢综合症是一组代谢危险因素，它们集合在一个人中。因此，在本研究中，已经根据WHO标准在2型糖尿病患者中进行了代谢综合征的发生。比较了患有和不患有代谢综合征的2型糖尿病患者的危险因素。材料与方法：该研究纳入了八名七岁，年龄匹配的2型糖尿病患者。根据WHO标准，将他们分为具有代谢综合征的糖尿病患者和没有代谢综合征的糖尿病患者。通过使用诊断试剂盒评估了诸如空腹血糖（FBS），餐后血糖（PPBS）和脂质分布等生化参数。测量血压（BP），并计算体重指数（BMI）和血浆动脉粥样硬化指数（AIP）。统计分析由学生的t检验完成。结果：2型糖尿病患者代谢综合征的发生率为33％。在患有代谢的2型糖尿病患者中，甘油三酸酯（TGL），极低密度脂蛋白（VLDLs），TGL / HDL比，AIP，BP和BMI显着增加，而高密度脂蛋白（HDLs）则下降与没有代谢综合征的2型糖尿病患者相比，该综合征更为明显。结论：与无代谢综合征的2型糖尿病患者相比，代谢综合征的糖尿病患者的TGL，TGL / HDL比值，AIP，BP和BMI显着提高，预示着2型糖尿病合并代谢综合征的患者患冠心病（CHD）的风险较高。

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