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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Central Nervous System Cryptococcosis among a Cohort of HIV Infected Patients from a University Hospital of North India
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Central Nervous System Cryptococcosis among a Cohort of HIV Infected Patients from a University Hospital of North India

机译：来自北印度大学医院的一批HIV感染患者中的中枢神经系统隐球菌病

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Background: Cryptococcus neoformans is a ubiquitous encap-sulated yeast that causes significant infections which range from asymptomatic pulmonary colonization to the life threatening meningoencephalitis, especially in immunocompromised indi-viduals. Cryptococcal meningitis is one of the AIDS-defining illnesses. Recent data have indicated that, the incidence of the cryptococcal infection is high in developing countries like India. We conducted this study to find out the incidence of cryptococcosis in this area. Material and Methods: The Cerebrospinal Fluid (CSF) specimens were collected from known HIV positive cases that had a clinical diagnosis of meningitis and they were processed by standard microbiological procedures. The cryptococcal isolates were identified by microscopy, their cultural characteristics, sugar assimilation and by the hydrolysis of urea. Results: The incidence of cryptococcal meningitis was 12.9%. All the strains were susceptible to amphotericin B, fluconazole, itraconazole and voriconazole. Conclusion: The cryptococcal infection should be suspected in all cases of meningitis, especially among HIV infected persons. An early diagnosis and treatment may alter the prognosis of these patients and hence, an examination of the CSF for cryptococcosis should be considered in all the HIV infected persons who have the symptoms of meningitis.
机译：背景：新隐球菌是一种无处不在的胶囊化酵母，可引起严重感染，包括无症状肺部定植到威胁生命的脑膜脑炎，尤其是免疫功能低下的个体。隐球菌性脑膜炎是定义艾滋病的疾病之一。最近的数据表明，在像印度这样的发展中国家，隐球菌感染的发生率很高。我们进行了这项研究，以找出该地区隐球菌病的发生率。材料和方法：脑脊液（CSF）标本取自具有临床诊断为脑膜炎的已知HIV阳性病例，并通过标准微生物程序进行处理。隐球菌分离物通过显微镜，其培养特征，糖同化作用和尿素的水解进行鉴定。结果：隐球菌性脑膜炎的发生率为12.9％。所有菌株均对两性霉素B，氟康唑，伊曲康唑和伏立康唑敏感。结论：在所有脑膜炎病例中均应怀疑隐球菌感染，尤其是在HIV感染者中。早期诊断和治疗可能会改变这些患者的预后，因此，对于所有患有脑膜炎症状的HIV感染者，都应考虑检查CSF是否有隐球菌病。

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